TACC3 and KAT2A

Number of citations of the paper that reports this interaction (PubMedID 14767476)
17

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		TACC3	KAT2A
Description		transforming acidic coiled-coil containing protein 3	lysine acetyltransferase 2A
Image
GO Annotations	Cellular Component	Spindle Pole Cytoplasm Cytosol Centriolar Satellite Intracellular Membrane-bounded Organelle Mitotic Spindle	Histone Acetyltransferase Complex Nuclear Chromatin Extracellular Space Nucleus Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex Centrosome STAGA Complex Transcription Factor TFTC Complex Oxoglutarate Dehydrogenase Complex Mitotic Spindle
	Molecular Function	Protein Binding	Chromatin Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Transcription Factor Binding H3 Histone Acetyltransferase Activity Protein Phosphatase Binding Histone Deacetylase Binding Histone Acetyltransferase Activity (H4-K12 Specific) Peptide-lysine-N-acetyltransferase Activity Histone Succinyltransferase Activity
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Spindle Organization Metaphase/anaphase Transition Of Mitotic Cell Cycle Cell Proliferation Cerebral Cortex Development Cell Division Regulation Of Mitotic Spindle Organization Microtubule Cytoskeleton Organization Involved In Mitosis	In Utero Embryonic Development Somitogenesis Cytokine Production Neural Tube Closure Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Heart Development Long-term Memory Cell Proliferation Response To Organic Cyclic Compound Viral Process Histone Acetylation Histone Deubiquitination Protein Deubiquitination Internal Peptidyl-lysine Acetylation Telencephalon Development Metencephalon Development Midbrain Development Positive Regulation Of Cell Projection Organization Regulation Of Protein Stability Response To Nutrient Levels Positive Regulation Of Histone Acetylation Multicellular Organism Growth Histone H3 Acetylation Histone H4-K12 Acetylation Histone H3-K14 Acetylation Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Gluconeogenesis Positive Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Centriole Replication Regulation Of Synaptic Plasticity Intracellular Distribution Of Mitochondria Regulation Of T Cell Activation Limb Development Regulation Of Cartilage Development Cellular Response To Tumor Necrosis Factor Alpha-tubulin Acetylation Histone Succinylation Regulation Of Bone Development Cellular Response To Nerve Growth Factor Stimulus Regulation Of Stem Cell Population Maintenance Positive Regulation Of Cardiac Muscle Cell Differentiation
Pathways		NOTCH3 Activation and Transmission of Signal to the Nucleus Negative regulation of NOTCH4 signaling	Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HATs acetylate histones Notch-HLH transcription pathway B-WICH complex positively regulates rRNA expression Ub-specific processing proteases RNA Polymerase I Transcription Initiation RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription
Drugs			Coenzyme A
Diseases
GWAS		Bladder cancer ( 24163127 20972438) Urinary bladder cancer ( 20348956)	Coronary artery disease ( 29212778) Inflammatory bowel disease ( 26278503) Vitiligo ( 27723757) vWF and FVIII levels ( 30586737)
Interacting Genes		16 interacting genes: AKAP9 ARNT ARNT2 ASPSCR1 AURKA CIB3 CLIP4 EIF3C KAT2A KIZ NDEL1 NOD2 SNX20 TBC1D22B TTF2 VPS37C	60 interacting genes: AKT1 ATXN7 BATF2 BECN1 CCND2 CCNE1 CDK2 CDK6 CDKN2B CEBPB COMMD1 CREBBP CRX CTNNB1 CUL2 DTL EID1 EP300 FZR1 GATA2 GRM1 H1-5 H2AC20 H2BC21 H3-4 H3C14 H4-16 H4C14 HSD11B2 IRF1 IRF2 IRF7 KDELR2 LATS2 MAP2K3 MAPK14 MYB MYC NF2 NOTCH1 PBX1 PPARG PRKDC PYGO2 RASSF1 RBPJ RELA SIRT2 STK11 TACC1 TACC2 TACC3 TADA2A TCF3 TP53 TRRAP TSC1 TTYH2 UBE2I XRCC6
Entrez ID		10460	2648
HPRD ID		05601	03807
Ensembl ID		ENSG00000013810	ENSG00000108773
Uniprot IDs		Q9Y6A5	Q92830
PDB IDs		5LXN 5LXO 5ODS 5ODT	1F68 1Z4R 3D7C 5H84 5H86 5MLJ 5TRL 5TRM 6J3P
Enriched GO Terms of Interacting Partners?
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