DYNLL1 and MYO5A

Number of citations of the paper that reports this interaction (PubMedID 10844022)
73

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		DYNLL1	MYO5A
Description		dynein light chain LC8-type 1	myosin VA
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GO Annotations	Cellular Component	Kinetochore Nucleus Cytoplasm Mitochondrion Centrosome Cytosol Cytoplasmic Dynein Complex Microtubule Plasma Membrane Cilium COP9 Signalosome Membrane Dynein Complex Tertiary Granule Membrane Mitotic Spindle Ciliary Tip Ficolin-1-rich Granule Membrane	Ruffle Photoreceptor Outer Segment Cell Cytoplasm Lysosome Early Endosome Late Endosome Peroxisome Endoplasmic Reticulum Smooth Endoplasmic Reticulum Golgi Apparatus Cytosol Intermediate Filament Actin Filament Actin Cytoskeleton Membrane Unconventional Myosin Complex Growth Cone Vesicle Filopodium Tip Insulin-responsive Compartment Microtubule Plus-end Melanosome Actomyosin Neuron Projection Neuronal Cell Body Recycling Endosome Extracellular Exosome Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding	Microfilament Motor Activity RNA Binding Calcium Ion Binding Protein Binding Calmodulin Binding ATP Binding Rab GTPase Binding Actin-dependent ATPase Activity Identical Protein Binding Actin Filament Binding Disordered Domain Specific Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle ER To Golgi Vesicle-mediated Transport Apoptotic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Viral Process Macroautophagy Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Substantia Nigra Development Intraciliary Transport Involved In Cilium Assembly Negative Regulation Of Phosphorylation Neutrophil Degranulation Ciliary Basal Body-plasma Membrane Docking Positive Regulation Of ATP-dependent Microtubule Motor Activity, Plus-end-directed	Exocytosis Post-Golgi Vesicle-mediated Transport Actin Filament Organization Chemical Synaptic Transmission Visual Perception Vesicle-mediated Transport Actin Filament-based Movement Vesicle Transport Along Actin Filament Insulin Secretion Melanocyte Differentiation Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Locomotion Involved In Locomotory Behavior Secretory Granule Localization Melanosome Transport Cellular Response To Insulin Stimulus Melanin Biosynthetic Process Odontogenesis Myelination Long-chain Fatty Acid Biosynthetic Process Hair Follicle Maturation Synapse Organization Protein Localization To Plasma Membrane Establishment Of Endoplasmic Reticulum Localization To Postsynapse Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Regulation Of Golgi Organization
Pathways		Activation of BIM and translocation to mitochondria Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Macroautophagy MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Intraflagellar transport RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation	Translocation of SLC2A4 (GLUT4) to the plasma membrane Regulation of actin dynamics for phagocytic cup formation Insulin processing FCGR3A-mediated phagocytosis
Drugs
Diseases			Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS		High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Reading disability or specific language impairment (pleiotropy) ( 25065397) Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy) ( 25065397) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)	Metabolite levels (Pyroglutamine) ( 23934736)
Interacting Genes		79 interacting genes: ACTB ACTC1 ACTG1 ALDOA AMOTL2 B3GALT4 BCAS1 BCL2L11 BMF CA2 CACNB1 CLIP2 CS DAZ1 DLG4 DLGAP1 DNAJB9 DNM2 DNM3 DNMT1 DYNC1H1 DYNC1I1 EEF1A1 ERG28 GAPDH GLUD1 GLUL GPHN GRIN3A HIP1R HSPA8 IHO1 INPP1 IQUB KANK2 LDHA MAP1B MARK3 MAST2 ME2 MRE11 MTA1 MTR MYO10 MYO5A NDEL1 NDUFA4L2 NFKBIA NOS1 NRF1 NTRK1 NTRK2 NTRK3 PAK1 PAN2 PARD3 PAX6 PCM1 PFKM PFKP PKIA PKIB PKIG POLH RAB4A RACK1 RGS2 SHROOM3 TERT THAP8 TNFRSF14 TP53BP1 TUBA3C TUBB TXNDC17 VIM ZHX1 ZMYND11 ZNF354A	14 interacting genes: AKAP9 BMF CALM1 DLGAP1 DYNLL1 DYNLL2 MLPH NDEL1 NEFL PRPH RAB11A RAB27A TRIM2 TRIM3
Entrez ID		8655	4644
HPRD ID		03334	01179
Ensembl ID		ENSG00000088986	ENSG00000197535
Uniprot IDs		P63167 Q6FGH9	A8CDT9 Q9UES4 Q9Y4I1
PDB IDs		1CMI 3ZKE 3ZKF 6GZJ 6GZL 6RLB 6SC2	4D07 4J5L 4LLI 4LX1 4LX2 5JCY 5JCZ
Enriched GO Terms of Interacting Partners?
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