DYNLL1 and ME2

Number of citations of the paper that reports this interaction (PubMedID 14760703)
28

Data Source:
HPRD (in vitro)

		DYNLL1	ME2
Description		dynein light chain LC8-type 1	malic enzyme 2
Image
GO Annotations	Cellular Component	Kinetochore Nucleus Cytoplasm Mitochondrion Centrosome Cytosol Cytoplasmic Dynein Complex Microtubule Plasma Membrane Cilium COP9 Signalosome Membrane Dynein Complex Tertiary Granule Membrane Mitotic Spindle Ciliary Tip Ficolin-1-rich Granule Membrane	Mitochondrion Mitochondrial Matrix Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding	Malic Enzyme Activity Malate Dehydrogenase (decarboxylating) (NAD+) Activity Malate Dehydrogenase (decarboxylating) (NADP+) Activity Oxaloacetate Decarboxylase Activity Electron Transfer Activity Metal Ion Binding NAD Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle ER To Golgi Vesicle-mediated Transport Apoptotic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Viral Process Macroautophagy Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Substantia Nigra Development Intraciliary Transport Involved In Cilium Assembly Negative Regulation Of Phosphorylation Neutrophil Degranulation Ciliary Basal Body-plasma Membrane Docking Positive Regulation Of ATP-dependent Microtubule Motor Activity, Plus-end-directed	Pyruvate Metabolic Process Tricarboxylic Acid Cycle Malate Metabolic Process Electron Transport Chain Regulation Of NADP Metabolic Process
Pathways		Activation of BIM and translocation to mitochondria Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Macroautophagy MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Intraflagellar transport RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation	Citric acid cycle (TCA cycle)
Drugs			NADH Fumaric Acid Malate Ion Alpha-Ketomalonic Acid Tartronate
Diseases
GWAS		High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Reading disability or specific language impairment (pleiotropy) ( 25065397) Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy) ( 25065397) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)	Entorhinal cortical thickness ( 21116278) Metabolite levels ( 23823483) Pneumococcal meningitis ( 31092817)
Interacting Genes		79 interacting genes: ACTB ACTC1 ACTG1 ALDOA AMOTL2 B3GALT4 BCAS1 BCL2L11 BMF CA2 CACNB1 CLIP2 CS DAZ1 DLG4 DLGAP1 DNAJB9 DNM2 DNM3 DNMT1 DYNC1H1 DYNC1I1 EEF1A1 ERG28 GAPDH GLUD1 GLUL GPHN GRIN3A HIP1R HSPA8 IHO1 INPP1 IQUB KANK2 LDHA MAP1B MARK3 MAST2 ME2 MRE11 MTA1 MTR MYO10 MYO5A NDEL1 NDUFA4L2 NFKBIA NOS1 NRF1 NTRK1 NTRK2 NTRK3 PAK1 PAN2 PARD3 PAX6 PCM1 PFKM PFKP PKIA PKIB PKIG POLH RAB4A RACK1 RGS2 SHROOM3 TERT THAP8 TNFRSF14 TP53BP1 TUBA3C TUBB TXNDC17 VIM ZHX1 ZMYND11 ZNF354A	1 interacting genes: DYNLL1
Entrez ID		8655	4200
HPRD ID		03334	01103
Ensembl ID		ENSG00000088986	ENSG00000082212
Uniprot IDs		P63167 Q6FGH9	P23368
PDB IDs		1CMI 3ZKE 3ZKF 6GZJ 6GZL 6RLB 6SC2	1DO8 1EFK 1EFL 1GZ3 1GZ4 1PJ2 1PJ3 1PJ4 1PJL 1QR6
Enriched GO Terms of Interacting Partners?
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