MYO5A and DYNLL2

Number of citations of the paper that reports this interaction (PubMedID 10844022)
73

Data Source:
HPRD (two hybrid, in vitro)

		MYO5A	DYNLL2
Description		myosin VA	dynein light chain LC8-type 2
Image
GO Annotations	Cellular Component	Ruffle Photoreceptor Outer Segment Cell Cytoplasm Lysosome Early Endosome Late Endosome Peroxisome Endoplasmic Reticulum Smooth Endoplasmic Reticulum Golgi Apparatus Cytosol Intermediate Filament Actin Filament Actin Cytoskeleton Membrane Unconventional Myosin Complex Growth Cone Vesicle Filopodium Tip Insulin-responsive Compartment Microtubule Plus-end Melanosome Actomyosin Neuron Projection Neuronal Cell Body Recycling Endosome Extracellular Exosome Postsynapse Glutamatergic Synapse	Nucleus Centrosome Cytosol Cytoplasmic Dynein Complex Microtubule Plasma Membrane Cilium Postsynaptic Density Membrane Dynein Complex Myosin V Complex Ciliary Tip Postsynapse Glutamatergic Synapse
	Molecular Function	Microfilament Motor Activity RNA Binding Calcium Ion Binding Protein Binding Calmodulin Binding ATP Binding Rab GTPase Binding Actin-dependent ATPase Activity Identical Protein Binding Actin Filament Binding Disordered Domain Specific Binding	Protein Binding Identical Protein Binding Protein-containing Complex Binding Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding Scaffold Protein Binding
	Biological Process	Exocytosis Post-Golgi Vesicle-mediated Transport Actin Filament Organization Chemical Synaptic Transmission Visual Perception Vesicle-mediated Transport Actin Filament-based Movement Vesicle Transport Along Actin Filament Insulin Secretion Melanocyte Differentiation Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Locomotion Involved In Locomotory Behavior Secretory Granule Localization Melanosome Transport Cellular Response To Insulin Stimulus Melanin Biosynthetic Process Odontogenesis Myelination Long-chain Fatty Acid Biosynthetic Process Hair Follicle Maturation Synapse Organization Protein Localization To Plasma Membrane Establishment Of Endoplasmic Reticulum Localization To Postsynapse Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Regulation Of Golgi Organization	ER To Golgi Vesicle-mediated Transport Macroautophagy Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Intraciliary Transport Involved In Cilium Assembly Positive Regulation Of ATP-dependent Microtubule Motor Activity, Plus-end-directed
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Regulation of actin dynamics for phagocytic cup formation Insulin processing FCGR3A-mediated phagocytosis	Activation of BMF and translocation to mitochondria Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Macroautophagy MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) Intraflagellar transport RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
Drugs
Diseases		Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS		Metabolite levels (Pyroglutamine) ( 23934736)	Blood protein levels ( 30072576)
Interacting Genes		14 interacting genes: AKAP9 BMF CALM1 DLGAP1 DYNLL1 DYNLL2 MLPH NDEL1 NEFL PRPH RAB11A RAB27A TRIM2 TRIM3	21 interacting genes: BCL2L11 BMF C12orf40 DLGAP1 DNAL4 DYNC1I1 EWSR1 GPHN GPRIN2 HMBOX1 HOMER3 IHO1 MEOX2 MORN3 MYO5A PAK1 RASGRP3 SECISBP2L SKAP1 THAP10 XIAP
Entrez ID		4644	140735
HPRD ID		01179	06489
Ensembl ID		ENSG00000197535	ENSG00000264364
Uniprot IDs		A8CDT9 Q9UES4 Q9Y4I1	Q96FJ2
PDB IDs		4D07 4J5L 4LLI 4LX1 4LX2 5JCY 5JCZ	2XQQ 3P8M 4D07
Enriched GO Terms of Interacting Partners?
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