MYO5A

Description		myosin VA
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GO Annotations	Cellular Component	Ruffle Photoreceptor Outer Segment Cell Cytoplasm Lysosome Early Endosome Late Endosome Peroxisome Endoplasmic Reticulum Smooth Endoplasmic Reticulum Golgi Apparatus Cytosol Intermediate Filament Actin Filament Actin Cytoskeleton Membrane Unconventional Myosin Complex Growth Cone Vesicle Filopodium Tip Insulin-responsive Compartment Microtubule Plus-end Melanosome Actomyosin Neuron Projection Neuronal Cell Body Recycling Endosome Extracellular Exosome Postsynapse Glutamatergic Synapse
	Molecular Function	Microfilament Motor Activity RNA Binding Calcium Ion Binding Protein Binding Calmodulin Binding ATP Binding Rab GTPase Binding Actin-dependent ATPase Activity Identical Protein Binding Actin Filament Binding Disordered Domain Specific Binding
	Biological Process	Exocytosis Post-Golgi Vesicle-mediated Transport Actin Filament Organization Chemical Synaptic Transmission Visual Perception Vesicle-mediated Transport Actin Filament-based Movement Vesicle Transport Along Actin Filament Insulin Secretion Melanocyte Differentiation Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Locomotion Involved In Locomotory Behavior Secretory Granule Localization Melanosome Transport Cellular Response To Insulin Stimulus Melanin Biosynthetic Process Odontogenesis Myelination Long-chain Fatty Acid Biosynthetic Process Hair Follicle Maturation Synapse Organization Protein Localization To Plasma Membrane Establishment Of Endoplasmic Reticulum Localization To Postsynapse Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Regulation Of Golgi Organization
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Regulation of actin dynamics for phagocytic cup formation Insulin processing FCGR3A-mediated phagocytosis
Drugs
Diseases		Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS		Metabolite levels (Pyroglutamine) ( 23934736)
Interacting Genes		14 interacting genes: AKAP9 BMF CALM1 DLGAP1 DYNLL1 DYNLL2 MLPH NDEL1 NEFL PRPH RAB11A RAB27A TRIM2 TRIM3
Entrez ID		4644
HPRD ID		01179
Ensembl ID		ENSG00000197535
Uniprot IDs		A8CDT9 Q9UES4 Q9Y4I1
PDB IDs		4D07 4J5L 4LLI 4LX1 4LX2 5JCY 5JCZ
Enriched GO Terms of Interacting Partners?
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