NUMB and ITGB3

Number of citations of the paper that reports this interaction (PubMedID 12606711)
115

Data Source:
HPRD (in vitro)

		NUMB	ITGB3
Description		NUMB endocytic adaptor protein	integrin subunit beta 3
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GO Annotations	Cellular Component	Nucleus Cytoplasm Early Endosome Plasma Membrane Focal Adhesion Basolateral Plasma Membrane Extrinsic Component Of Plasma Membrane Clathrin-coated Vesicle Apical Part Of Cell Glutamatergic Synapse	Nucleus Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Focal Adhesion Integrin Complex Cell Surface Platelet Alpha Granule Membrane Lamellipodium Membrane Filopodium Membrane Microvillus Membrane Ruffle Membrane Protein-containing Complex Integrin Alphav-beta3 Complex Alphav-beta3 Integrin-PKCalpha Complex Alphav-beta3 Integrin-IGF-1-IGF1R Complex Alphav-beta3 Integrin-HMGB1 Complex Melanosome Receptor Complex Synapse Postsynaptic Membrane Extracellular Exosome Alphav-beta3 Integrin-vitronectin Complex Glutamatergic Synapse
	Molecular Function	Protein Binding Beta-catenin Binding Alpha-catenin Binding Cadherin Binding	Virus Receptor Activity Fibronectin Binding Protease Binding Protein Disulfide Isomerase Activity Platelet-derived Growth Factor Receptor Binding Integrin Binding Protein Binding Coreceptor Activity Fibroblast Growth Factor Binding Enzyme Binding C-X3-C Chemokine Binding Insulin-like Growth Factor I Binding Neuregulin Binding Identical Protein Binding Vascular Endothelial Growth Factor Receptor 2 Binding Cell Adhesion Molecule Binding Extracellular Matrix Binding Fibrinogen Binding
	Biological Process	Axonogenesis Lateral Ventricle Development Neuroblast Division In Subventricular Zone Positive Regulation Of Cell Migration Adherens Junction Organization Positive Regulation Of Neurogenesis Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Negative Regulation Of Protein Localization To Plasma Membrane	Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Platelet Degranulation Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Blood Coagulation Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Smooth Muscle Cell Migration Cell Migration Platelet Activation Extracellular Matrix Organization Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-substrate Adhesion Activation Of Protein Kinase Activity Negative Regulation Of Lipid Transport Regulation Of Protein Localization Cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Tube Development Apolipoprotein A-I-mediated Signaling Pathway Wound Healing Apoptotic Cell Clearance Regulation Of Bone Resorption Negative Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Viral Entry Into Host Cell Vascular Endothelial Growth Factor Receptor Signaling Pathway Mesodermal Cell Differentiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Lipoprotein Metabolic Process Leukocyte Migration Negative Chemotaxis Regulation Of Serotonin Uptake Angiogenesis Involved In Wound Healing Platelet Aggregation Regulation Of Postsynaptic Neurotransmitter Receptor Internalization
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus Recycling pathway of L1 Degradation of GLI1 by the proteasome Hedgehog 'on' state	Platelet degranulation Elastic fibre formation PECAM1 interactions Molecules associated with elastic fibres Integrin cell surface interactions Integrin cell surface interactions Syndecan interactions Syndecan interactions ECM proteoglycans Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins VEGFA-VEGFR2 Pathway Signal transduction by L1 MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants
Drugs			Abciximab Eptifibatide Antithymocyte immunoglobulin (rabbit) Tirofiban Resveratrol Lefradafiban LM-609
Diseases			Glanzmann thrombasthenia Allograft rejection
GWAS		Bipolar disorder with mood-incongruent psychosis ( 23092984) Coronary artery calcification ( 17903303) Macular thickness ( 30535121) Multisite chronic pain ( 31194737)	Body mass index ( 25673413) Chromosomal aberration frequency (chromosome type) in genotoxic compound exposure ( 31586183) High chromosomal aberration frequency (chromosome type) ( 31586183) Mean platelet volume ( 27863252) Medication use (thyroid preparations) ( 31015401) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		33 interacting genes: AP2A1 AP2A2 APP DNAJC5 DPYSL2 EGFR EPS15 FBXO7 FRS3 IRS1 ITCH ITGB2 ITGB3 ITGB5 L1CAM LNX1 LNX2 MAPK8IP2 MDM2 NEDD4 NOTCH1 OLIG1 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCZ PTEN RPL3 SIAH1 TERF2	49 interacting genes: AKT1 ANGPTL3 APP CAPN1 CD36 CDK1 COL1A2 DAB1 DAB2 DOK1 EPS8 FBLN2 FGA FGFR1 FGG FLNA FLNB FN1 GRIA2 HRAS ILK ITGA2B ITGA5 ITGAV ITGB3BP KDR MAPK3 NID1 NUMB P2RY2 P4HB PDGFRA PDGFRB PDK1 PDPK1 PECAM1 PLA2G2A PLA2G4A PTK2 PTK2B PXN SHC1 SRC TGM2 THBS1 THY1 TLN1 TNS2 VTN
Entrez ID		8650	3690
HPRD ID		04767	01428
Ensembl ID		ENSG00000133961	ENSG00000259207
Uniprot IDs		A0A024R681 A0A024R684 A0A024R6C4 A0A024R6F4 P49757	P05106
PDB IDs		5NJJ 5NJK	1JV2 1KUP 1KUZ 1L5G 1M1X 1M8O 1MIZ 1MK7 1MK9 1RN0 1S4X 1TYE 1U8C 2INI 2K9J 2KNC 2KV9 2L1C 2L91 2LJD 2LJE 2LJF 2MTP 2N9Y 2Q6W 2RMZ 2RN0 2VC2 2VDK 2VDL 2VDM 2VDN 2VDO 2VDP 2VDQ 2VDR 3FCS 3FCU 3IJE 3NID 3NIF 3NIG 3T3M 3T3P 3ZDX 3ZDY 3ZDZ 3ZE0 3ZE1 3ZE2 4CAK 4G1E 4G1M 4MMX 4MMY 4MMZ 4O02 4Z7N 4Z7O 4Z7Q 5HDB 6AVQ 6AVR 6AVU 6BXB 6BXF 6BXJ 6CKB 6MK0 6MSL 6MSU
Enriched GO Terms of Interacting Partners?
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