ZGPAT and UPF2

Number of citations of the paper that reports this interaction (PubMedID 15231747)
56

Data Source:
BioGRID (two hybrid)

		ZGPAT	UPF2
Description		zinc finger CCCH-type and G-patch domain containing	UPF2 regulator of nonsense mediated mRNA decay
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GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Plasma Membrane	Nucleus Cytoplasm Cytosol Polysome Exon-exon Junction Complex Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Metal Ion Binding	RNA Binding Protein Binding Telomeric DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Transcription, DNA-templated	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Liver Development MRNA Export From Nucleus Animal Organ Regeneration
Pathways			Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) C-reactive protein levels ( 30388399) Crohn's disease ( 28067908) Diverticular disease ( 30177863) Estimated glomerular filtration rate ( 31152163 31015462) Inflammatory bowel disease ( 28067908 23128233) Lung function (FEV1) ( 28166213) Prostate cancer ( 31562322 23535732) Ulcerative colitis ( 28067908 21297633)	Diverticular disease ( 30177863)
Interacting Genes		39 interacting genes: AIMP2 AMOTL2 BEND5 BLZF1 CCDC33 CCDC57 CCNDBP1 CDCA7L CDR2 CEP57L1 CEP70 CTNNA1 DHX15 DVL2 DYDC1 FAM9B GOLGA2 IHO1 IKZF3 KIFC3 KRT15 KRT40 LDOC1 LZTS2 MID2 MIPOL1 NEBL PHC2 PRPF3 SPAG5 SSX2IP STAC3 TFIP11 TLE5 TP53BP2 TRIM27 TRIM54 UPF2 ZBTB8A	75 interacting genes: ABCF2 AGPAT1 ART4 ATP1B3 BLM CALR CENPU CIZ1 COMTD1 CYBA DCP1B DCP2 DPF2 E4F1 EIF1 EIF4A1 EIF4G1 ENO1 EXOSC1 EXOSC10 EXOSC4 EXOSC6 EXOSC8 GADD45GIP1 HBZ HMGA1 HS3ST3A1 HSF2BP ITGB1 KRT18 LDHA LSM1 MAP1A MAP1LC3B MIF MRPL40 MTERF3 MTREX MYB NDUFA7 NOB1 NOMO1 NOP53 PHB2 PITX1 PUF60 RNPS1 RPL13 RPL5 RPL8 RPS15 RPS25 RPS6 RPS7 RRP7A RSRC2 SERBP1 SERF2 SMG1 SUMO3 TK1 TNNI2 TOP3B TUBB2A TYMS UPF1 UPF3B WNK1 XRN1 XRN2 ZBTB48 ZFP36 ZGPAT ZNF408 ZNF44
Entrez ID		84619	26019
HPRD ID		15736	10405
Ensembl ID		ENSG00000197114	ENSG00000151461
Uniprot IDs		A0A0S2Z5X3 Q8N5A5	Q9HAU5
PDB IDs		4II1	1UW4 2WJV 4CEK 4CEM
Enriched GO Terms of Interacting Partners?
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