UPF2 and MTREX

Number of citations of the paper that reports this interaction (PubMedID 15231747)
56

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		UPF2	MTREX
Description		UPF2 regulator of nonsense mediated mRNA decay	Mtr4 exosome RNA helicase
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Polysome Exon-exon Junction Complex Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Nuclear Speck TRAMP Complex Catalytic Step 2 Spliceosome
	Molecular Function	RNA Binding Protein Binding Telomeric DNA Binding	RNA Binding RNA Helicase Activity Protein Binding ATP Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Liver Development MRNA Export From Nucleus Animal Organ Regeneration	MRNA Splicing, Via Spliceosome Maturation Of 5.8S RRNA RRNA Processing RNA Catabolic Process SnRNA Catabolic Process
Pathways		Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Major pathway of rRNA processing in the nucleolus and cytosol mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Diverticular disease ( 30177863)
Interacting Genes		75 interacting genes: ABCF2 AGPAT1 ART4 ATP1B3 BLM CALR CENPU CIZ1 COMTD1 CYBA DCP1B DCP2 DPF2 E4F1 EIF1 EIF4A1 EIF4G1 ENO1 EXOSC1 EXOSC10 EXOSC4 EXOSC6 EXOSC8 GADD45GIP1 HBZ HMGA1 HS3ST3A1 HSF2BP ITGB1 KRT18 LDHA LSM1 MAP1A MAP1LC3B MIF MRPL40 MTERF3 MTREX MYB NDUFA7 NOB1 NOMO1 NOP53 PHB2 PITX1 PUF60 RNPS1 RPL13 RPL5 RPL8 RPS15 RPS25 RPS6 RPS7 RRP7A RSRC2 SERBP1 SERF2 SMG1 SUMO3 TK1 TNNI2 TOP3B TUBB2A TYMS UPF1 UPF3B WNK1 XRN1 XRN2 ZBTB48 ZFP36 ZGPAT ZNF408 ZNF44	16 interacting genes: DIS3 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FAM107A MPHOSPH6 MPP6 PBX2 SP1 UPF2 XRN1 ZCCHC8
Entrez ID		26019	23517
HPRD ID		10405	13777
Ensembl ID		ENSG00000151461	ENSG00000039123
Uniprot IDs		Q9HAU5	P42285 Q3MHC9
PDB IDs		1UW4 2WJV 4CEK 4CEM	6C90 6D6Q 6D6R 6IEG 6IEH 6RO1
Enriched GO Terms of Interacting Partners?
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