UPF2 and TYMS

Number of citations of the paper that reports this interaction (PubMedID 15231747)
56

Data Source:
BioGRID (two hybrid)

		UPF2	TYMS
Description		UPF2 regulator of nonsense mediated mRNA decay	thymidylate synthetase
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Polysome Exon-exon Junction Complex Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm	Nucleus Nucleolus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Cytosol
	Molecular Function	RNA Binding Protein Binding Telomeric DNA Binding	Nucleotide Binding Translation Repressor Activity, MRNA Regulatory Element Binding Thymidylate Synthase Activity Folic Acid Binding Identical Protein Binding Cofactor Binding Sequence-specific MRNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Liver Development MRNA Export From Nucleus Animal Organ Regeneration	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle DTMP Biosynthetic Process DTTP Biosynthetic Process Aging Circadian Rhythm Nucleobase-containing Small Molecule Interconversion Negative Regulation Of Translation Transformation Of Host Cell By Virus Uracil Metabolic Process Methylation Response To Progesterone Response To Vitamin A Response To Cytokine Tetrahydrofolate Interconversion Response To Ethanol DUMP Metabolic Process Response To Organophosphorus Developmental Growth Cartilage Development Response To Glucocorticoid Response To Folic Acid Intestinal Epithelial Cell Maturation DNA Biosynthetic Process Liver Regeneration
Pathways		Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Interconversion of nucleotide di- and triphosphates G1/S-Specific Transcription
Drugs			Raltitrexed Floxuridine Trifluridine Trimethoprim Gemcitabine Fluorouracil Pemetrexed Capecitabine Thymidine-5'-Phosphate 10-Propargyl-5,8-Dideazafolic Acid 2'-deoxyuridylic acid S,S-(2-Hydroxyethyl)Thiocysteine Thymectacin ANX-510 OSI-7904L Pralatrexate 6-ETHYL-5-PHENYLPYRIMIDINE-2,4-DIAMINE N-[2-chloro-5-(trifluoromethyl)phenyl]imidodicarbonimidic diamide N-(3,5-dimethoxyphenyl)imidodicarbonimidic diamide 6,6-DIMETHYL-1-[3-(2,4,5-TRICHLOROPHENOXY)PROPOXY]-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINE
Diseases
GWAS		Diverticular disease ( 30177863)	Leukocyte telomere length ( 31171785) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Testicular germ cell tumor ( 28604728) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		75 interacting genes: ABCF2 AGPAT1 ART4 ATP1B3 BLM CALR CENPU CIZ1 COMTD1 CYBA DCP1B DCP2 DPF2 E4F1 EIF1 EIF4A1 EIF4G1 ENO1 EXOSC1 EXOSC10 EXOSC4 EXOSC6 EXOSC8 GADD45GIP1 HBZ HMGA1 HS3ST3A1 HSF2BP ITGB1 KRT18 LDHA LSM1 MAP1A MAP1LC3B MIF MRPL40 MTERF3 MTREX MYB NDUFA7 NOB1 NOMO1 NOP53 PHB2 PITX1 PUF60 RNPS1 RPL13 RPL5 RPL8 RPS15 RPS25 RPS6 RPS7 RRP7A RSRC2 SERBP1 SERF2 SMG1 SUMO3 TK1 TNNI2 TOP3B TUBB2A TYMS UPF1 UPF3B WNK1 XRN1 XRN2 ZBTB48 ZFP36 ZGPAT ZNF408 ZNF44	2 interacting genes: SH3GL2 UPF2
Entrez ID		26019	7298
HPRD ID		10405	01774
Ensembl ID		ENSG00000151461	ENSG00000176890
Uniprot IDs		Q9HAU5	P04818 Q53Y97
PDB IDs		1UW4 2WJV 4CEK 4CEM	1HVY 1HW3 1HW4 1HZW 1I00 1JU6 1JUJ 1YPV 2ONB 2RD8 2RDA 3EAW 3EBU 3ED7 3EDW 3EF9 3EGY 3EHI 3EJL 3GG5 3GH0 3GH2 3H9K 3HB8 3N5E 3N5G 3OB7 4E28 4FGT 4G2O 4G6W 4GD7 4GYH 4H1I 4JEF 4KPW 4O1U 4O1X 4UP1 5HS3 5WRN 5X4W 5X4X 5X4Y 5X5A 5X5D 5X5Q 5X66 5X67 5X69 6OJU 6OJV 6PF3 6PF4 6PF5 6PF6 6QXG 6QXH 6QYQ 6R2E
Enriched GO Terms of Interacting Partners?
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