CUL4A and H1-2

Number of citations of the paper that reports this interaction (PubMedID 24360965)
22

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down, imaging technique)

		CUL4A	H1-2
Description		cullin 4A	H1.2 linker histone, cluster member
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm SCF Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex Cul4-RING E3 Ubiquitin Ligase Complex	Nucleosome Nuclear Chromatin Nucleus Nuclear Euchromatin Transcriptionally Active Chromatin
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	Double-stranded DNA Binding RNA Binding Protein Binding Chromatin DNA Binding Nucleosomal DNA Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Nucleotide-excision Repair, DNA Damage Recognition Nucleotide-excision Repair, DNA Duplex Unwinding In Utero Embryonic Development Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair, Preincision Complex Stabilization Nucleotide-excision Repair, Preincision Complex Assembly Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Positive Regulation Of Cell Proliferation Viral Process Protein Ubiquitination Hemopoiesis Negative Regulation Of Granulocyte Differentiation SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Nucleotide-excision Repair, DNA Incision Somatic Stem Cell Population Maintenance Ribosome Biogenesis DNA Damage Response, Detection Of DNA Damage Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Rhythmic Process Regulation Of Protein Metabolic Process Global Genome Nucleotide-excision Repair Intrinsic Apoptotic Signaling Pathway Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Damage Checkpoint Regulation Of Nucleotide-excision Repair	Negative Regulation Of Transcription By RNA Polymerase II Nucleosome Assembly Regulation Of Transcription, DNA-templated Nucleosome Positioning Chromosome Condensation Negative Regulation Of Chromatin Silencing Negative Regulation Of DNA Recombination Histone H3-K4 Trimethylation Histone H3-K27 Trimethylation
Pathways		Recognition of DNA damage by PCNA-containing replication complex DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neddylation	Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs
Diseases
GWAS		Atrial fibrillation ( 30061737) Bipolar disorder ( 31043756) Blood protein levels ( 28240269) Intracranial aneurysm ( 30823506) Platelet distribution width ( 27863252)
Interacting Genes		23 interacting genes: CAND1 CDKN1B CENPA CHEK1 COMMD1 DCAF6 DCUN1D4 DDB1 DDB2 ERCC8 GPS1 H1-2 H3C1 HOXA9 PHIP RBX1 RNF7 SALL2 SENP8 SKP2 TUBG1 UBC UBE2E3	30 interacting genes: AEBP2 APP ASXL1 CDC73 CSNK2A2 CTNNB1 CTR9 CUL4A DDB1 F10 IL7R IRAK4 KPNA7 KPNB1 LEO1 NASP NCL NSD1 PAF1 PARP1 POLR2A PRKCA PRKDC PUF60 RBM39 SNCA VHL WDR12 WDR5 YBX1
Entrez ID		8451	3006
HPRD ID		07218	07514
Ensembl ID		ENSG00000139842	ENSG00000187837
Uniprot IDs		A0A0A0MR50 Q13619	P16403
PDB IDs		2HYE 4A0K
Enriched GO Terms of Interacting Partners?
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