H1-2 and ASXL1

Number of citations of the paper that reports this interaction (PubMedID 18258596)
47

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		H1-2	ASXL1
Description		H1.2 linker histone, cluster member	ASXL transcriptional regulator 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleosome Nuclear Chromatin Nucleus Nuclear Euchromatin Transcriptionally Active Chromatin	Nuclear Chromatin Nucleoplasm PR-DUB Complex
	Molecular Function	Double-stranded DNA Binding RNA Binding Protein Binding Chromatin DNA Binding Nucleosomal DNA Binding	DNA Binding Chromatin Binding Transcription Coactivator Activity Protein Binding Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Nucleosome Assembly Regulation Of Transcription, DNA-templated Nucleosome Positioning Chromosome Condensation Negative Regulation Of Chromatin Silencing Negative Regulation Of DNA Recombination Histone H3-K4 Trimethylation Histone H3-K27 Trimethylation	Cell Morphogenesis Heart Morphogenesis Transcription, DNA-templated Animal Organ Morphogenesis Negative Regulation Of Lipid Storage Protein Deubiquitination Hemopoiesis Response To Retinoic Acid Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Monoubiquitinated Histone H2A Deubiquitination Regulation Of Kidney Size Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Thymus Development Bone Marrow Development Homeostasis Of Number Of Cells Lung Saccule Development Glomerular Visceral Epithelial Cell Development
Pathways		Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)	UCH proteinases
Drugs
Diseases			C syndrome, including: Opitz trigonocephaly syndrome; Bohring-Opitz syndrome (BOPS)
GWAS			Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Inflammatory bowel disease ( 28067908)
Interacting Genes		30 interacting genes: AEBP2 APP ASXL1 CDC73 CSNK2A2 CTNNB1 CTR9 CUL4A DDB1 F10 IL7R IRAK4 KPNA7 KPNB1 LEO1 NASP NCL NSD1 PAF1 PARP1 POLR2A PRKCA PRKDC PUF60 RBM39 SNCA VHL WDR12 WDR5 YBX1	5 interacting genes: APP H1-2 SRPK1 STAT3 UBC
Entrez ID		3006	171023
HPRD ID		07514	16516
Ensembl ID		ENSG00000187837	ENSG00000171456
Uniprot IDs		P16403	Q498B9 Q8IXJ9
PDB IDs
Enriched GO Terms of Interacting Partners?
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