H1-2 and CSNK2A2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		H1-2	CSNK2A2
Description		H1.2 linker histone, cluster member	casein kinase 2 alpha 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleosome Nuclear Chromatin Nucleus Nuclear Euchromatin Transcriptionally Active Chromatin	Chromatin Acrosomal Vesicle Nucleus Nucleoplasm Cytosol Plasma Membrane PcG Protein Complex
	Molecular Function	Double-stranded DNA Binding RNA Binding Protein Binding Chromatin DNA Binding Nucleosomal DNA Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein N-terminus Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Nucleosome Assembly Regulation Of Transcription, DNA-templated Nucleosome Positioning Chromosome Condensation Negative Regulation Of Chromatin Silencing Negative Regulation Of DNA Recombination Histone H3-K4 Trimethylation Histone H3-K27 Trimethylation	Protein Folding Phosphatidylcholine Biosynthetic Process Apoptotic Process Cell Cycle Spermatogenesis Wnt Signaling Pathway Macroautophagy Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Cerebral Cortex Development Regulation Of Cell Cycle Liver Regeneration Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Protein Targeting To Mitochondrion Regulation Of Chromosome Separation Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)	Synthesis of PC WNT mediated activation of DVL Condensation of Prometaphase Chromosomes Signal transduction by L1 Regulation of TP53 Activity through Phosphorylation Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Receptor Mediated Mitophagy RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN stability and activity
Drugs			[1-(6-{6-[(1-methylethyl)amino]-1H-indazol-1-yl}pyrazin-2-yl)-1H-pyrrol-3-yl]acetic acid
Diseases
GWAS			Primary biliary cholangitis ( 28425483) Rosacea symptom severity ( 29771307) Systemic lupus erythematosus ( 28714469) Telomere length ( 24795349)
Interacting Genes		30 interacting genes: AEBP2 APP ASXL1 CDC73 CSNK2A2 CTNNB1 CTR9 CUL4A DDB1 F10 IL7R IRAK4 KPNA7 KPNB1 LEO1 NASP NCL NSD1 PAF1 PARP1 POLR2A PRKCA PRKDC PUF60 RBM39 SNCA VHL WDR12 WDR5 YBX1	103 interacting genes: ABCA1 ACACA ADH1A AMFR AQP4 ARRB2 ASL ATF1 ATF2 ATG16L1 BHLHE41 BID CABP1 CALM1 CASQ2 CAV1 CDC37 CLTB CREBBP CREM CSN3 CSNK2B CTDP1 DCPS DELEC1 EEF1B2 EIF2B2 EIF2B5 EIF4EBP1 ERH FGF1 FGF2 FKBP3 FOS GOT2 GTF2A1 GTF2A1L H1-2 HDAC1 HDAC2 HDAC6 HMGA1 HMGA2 HNRNPC HSP90AA1 HSP90B1 HSPH1 IL16 KDM1A KIF1C KLF1 LAMC3 LGALS3 MAF1 MAPK14 MDM2 MGMT MS4A1 MYC MYCN MYF5 NAP1L4 NCL NR1D2 P4HB PAK1 PIN1 PIN4 PPP1R1B PPP1R2 PPP1R8 PRNP PTEN PTPN1 PTPRC RAD1 RAD9A RELA RGS19 SAT1 SLC18A2 SMURF1 SNCA SNX6 SPIB SPP1 STX1A TCF7L2 TCOF1 TGFBR1 TGM2 TOP1 TP53 TP63 TRIM41 TTLL12 UBE2R2 WAS XRCC1 ZNF219 ZNF423 ZNF670 ZNHIT3
Entrez ID		3006	1459
HPRD ID		07514	00279
Ensembl ID		ENSG00000187837	ENSG00000070770
Uniprot IDs		P16403	P19784
PDB IDs			3E3B 3OFM 3U87 5M4U 5M56 5OOI 5Y9M 5YF9 5YWM 6HMB 6HMC 6HMD 6HMQ 6QY9
Enriched GO Terms of Interacting Partners?
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