ULK1 and SYNGAP1

Number of citations of the paper that reports this interaction (PubMedID 15014045)
75

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		ULK1	SYNGAP1
Description		unc-51 like autophagy activating kinase 1	synaptic Ras GTPase activating protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Phagophore Assembly Site Cytoplasm Mitochondrial Outer Membrane Autophagosome Endoplasmic Reticulum Membrane Cytosol Membrane Axon Guanyl-nucleotide Exchange Factor Complex Phagophore Assembly Site Membrane Recycling Endosome Extrinsic Component Of Omegasome Membrane Extrinsic Component Of Phagophore Assembly Site Membrane Extrinsic Component Of Autophagosome Membrane Atg1/ULK1 Kinase Complex	Cytosol Plasma Membrane Postsynaptic Density Dendritic Shaft Glutamatergic Synapse
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Rab GTPase Binding Identical Protein Binding Protein-containing Complex Binding GTPase Binding	GTPase Activator Activity SH3 Domain Binding
	Biological Process	Autophagosome Assembly Protein Phosphorylation Autophagy Signal Transduction Protein Localization Regulation Of Autophagy Positive Regulation Of Autophagy Macroautophagy Regulation Of Macroautophagy Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Neuron Projection Regeneration Neuron Projection Development Negative Regulation Of Protein Complex Assembly Cellular Response To Nutrient Levels Response To Starvation Protein Autophosphorylation Axon Extension Autophagy Of Host Cells Involved In Interaction With Symbiont Positive Regulation Of Autophagosome Assembly	MAPK Cascade Ras Protein Signal Transduction Pattern Specification Process Visual Learning Dendrite Development Receptor Clustering Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity Negative Regulation Of Ras Protein Signal Transduction Regulation Of Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Axonogenesis Regulation Of Synapse Structure Or Activity Maintenance Of Postsynaptic Specialization Structure
Pathways		Macroautophagy TBC/RABGAPs RAB GEFs exchange GTP for GDP on RABs Receptor Mediated Mitophagy	Regulation of RAS by GAPs
Drugs
Diseases			Non-syndromic autosomal dominant mental retardation
GWAS		Body mass index ( 26426971) Mercury levels ( 26025379)	Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Late-onset Alzheimer's disease ( 27770636) Schizophrenia ( 30285260)
Interacting Genes		23 interacting genes: ATG13 ATG9A BECN1 EXOC8 GABARAP GABARAPL1 GABARAPL2 MAP1LC3A MAP1LC3B MAP1LC3C MAPK14 MBP MEFV MUL1 NEDD4L OCLN PPP1CA PRKAA1 SDCBP SMCR8 SYNGAP1 UBC USP20	13 interacting genes: CAMK2A DLG3 DLG4 DLGAP4 GRIN1 GRIN2B GRIN2D KDR MPDZ PDGFRB TRIP6 ULK1 ULK2
Entrez ID		8408	8831
HPRD ID		11933	16018
Ensembl ID		ENSG00000177169	ENSG00000197283
Uniprot IDs		O75385	A0A1U9X8L0 B7ZCA0 Q96PV0
PDB IDs		4WNO 4WNP 5CI7 6HYO 6MNH 6QAS
Enriched GO Terms of Interacting Partners?
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