ULK1 and MUL1

Number of citations of the paper that reports this interaction (PubMedID 26018823)
33

Data Source:
BioGRID (enzymatic study)

		ULK1	MUL1
Description		unc-51 like autophagy activating kinase 1	mitochondrial E3 ubiquitin protein ligase 1
Image
GO Annotations	Cellular Component	Phagophore Assembly Site Cytoplasm Mitochondrial Outer Membrane Autophagosome Endoplasmic Reticulum Membrane Cytosol Membrane Axon Guanyl-nucleotide Exchange Factor Complex Phagophore Assembly Site Membrane Recycling Endosome Extrinsic Component Of Omegasome Membrane Extrinsic Component Of Phagophore Assembly Site Membrane Extrinsic Component Of Autophagosome Membrane Atg1/ULK1 Kinase Complex	Mitochondrion Peroxisome Membrane Axon Integral Component Of Mitochondrial Outer Membrane Neuronal Cell Body
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Rab GTPase Binding Identical Protein Binding Protein-containing Complex Binding GTPase Binding	Ubiquitin-protein Transferase Activity Protein Binding SUMO Transferase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Autophagosome Assembly Protein Phosphorylation Autophagy Signal Transduction Protein Localization Regulation Of Autophagy Positive Regulation Of Autophagy Macroautophagy Regulation Of Macroautophagy Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Neuron Projection Regeneration Neuron Projection Development Negative Regulation Of Protein Complex Assembly Cellular Response To Nutrient Levels Response To Starvation Protein Autophosphorylation Axon Extension Autophagy Of Host Cells Involved In Interaction With Symbiont Positive Regulation Of Autophagosome Assembly	Mitochondrial Fission Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of JUN Kinase Activity Negative Regulation Of Mitochondrial Fusion Regulation Of Mitochondrion Organization Protein Ubiquitination Protein Sumoylation Negative Regulation Of Cell Growth Protein Destabilization Positive Regulation Of Protein Sumoylation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Innate Immune Response Negative Regulation Of Defense Response To Virus By Host Protein Stabilization Mitochondrion Localization Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Exogenous DsRNA Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Mitochondrial Fission Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Dendrite Extension Positive Regulation Of Autophagy Of Mitochondrion In Response To Mitochondrial Depolarization
Pathways		Macroautophagy TBC/RABGAPs RAB GEFs exchange GTP for GDP on RABs Receptor Mediated Mitophagy	Ub-specific processing proteases
Drugs
Diseases
GWAS		Body mass index ( 26426971) Mercury levels ( 26025379)
Interacting Genes		23 interacting genes: ATG13 ATG9A BECN1 EXOC8 GABARAP GABARAPL1 GABARAPL2 MAP1LC3A MAP1LC3B MAP1LC3C MAPK14 MBP MEFV MUL1 NEDD4L OCLN PPP1CA PRKAA1 SDCBP SMCR8 SYNGAP1 UBC USP20	30 interacting genes: AKT1 APPBP2 CDC34 DNM1L EHD1 HTRA2 MAP3K7 STING1 SUMO1 TAP1 TP53 TP73 TRIM9 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2L3 UBE2L6 UBE2N UBE2R2 UBE2U UBE2V2 UBE2W ULK1
Entrez ID		8408	79594
HPRD ID		11933	07799
Ensembl ID		ENSG00000177169	ENSG00000090432
Uniprot IDs		O75385	A1PUM0 Q969V5
PDB IDs		4WNO 4WNP 5CI7 6HYO 6MNH 6QAS	6K2K
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?