SYNGAP1 and MPDZ

Number of citations of the paper that reports this interaction (PubMedID 15312654)
97

Data Source:
HPRD (in vitro, in vivo)

		SYNGAP1	MPDZ
Description		synaptic Ras GTPase activating protein 1	multiple PDZ domain crumbs cell polarity complex component
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Postsynaptic Density Dendritic Shaft Glutamatergic Synapse	Cytoplasm Bicellular Tight Junction Postsynaptic Density Apical Plasma Membrane Apicolateral Plasma Membrane Dendrite Cytoplasmic Vesicle Schmidt-Lanterman Incisure
	Molecular Function	GTPase Activator Activity SH3 Domain Binding	Protein Binding Protein C-terminus Binding
	Biological Process	MAPK Cascade Ras Protein Signal Transduction Pattern Specification Process Visual Learning Dendrite Development Receptor Clustering Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity Negative Regulation Of Ras Protein Signal Transduction Regulation Of Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Axonogenesis Regulation Of Synapse Structure Or Activity Maintenance Of Postsynaptic Specialization Structure	Cell Adhesion Viral Process
Pathways		Regulation of RAS by GAPs
Drugs
Diseases		Non-syndromic autosomal dominant mental retardation
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Late-onset Alzheimer's disease ( 27770636) Schizophrenia ( 30285260)	Central corneal thickness ( 29760442) Corneal hysteresis ( 30894546) Corneal structure ( 23291589) Heel bone mineral density ( 30598549 28869591) Refractive astigmatism ( 30306274)
Interacting Genes		13 interacting genes: CAMK2A DLG3 DLG4 DLGAP4 GRIN1 GRIN2B GRIN2D KDR MPDZ PDGFRB TRIP6 ULK1 ULK2	16 interacting genes: ABCA1 CAMK2A CLDN1 CLDN5 CRHR1 CSPG4 DRD3 F11R HTR2C KIT MTNR1A PLEKHA1 PLEKHA2 RNF5 SYNGAP1 TSC22D2
Entrez ID		8831	8777
HPRD ID		16018	09155
Ensembl ID		ENSG00000197283	ENSG00000107186
Uniprot IDs		A0A1U9X8L0 B7ZCA0 Q96PV0	O75970
PDB IDs			2FCF 2FNE 2IWN 2IWO 2IWP 2IWQ 2O2T 2OPG 2QG1
Enriched GO Terms of Interacting Partners?
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