ULK1 and ATG13

Number of citations of the paper that reports this interaction (PubMedID 21460634)
67

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study)

		ULK1	ATG13
Description		unc-51 like autophagy activating kinase 1	autophagy related 13
Image
GO Annotations	Cellular Component	Phagophore Assembly Site Cytoplasm Mitochondrial Outer Membrane Autophagosome Endoplasmic Reticulum Membrane Cytosol Membrane Axon Guanyl-nucleotide Exchange Factor Complex Phagophore Assembly Site Membrane Recycling Endosome Extrinsic Component Of Omegasome Membrane Extrinsic Component Of Phagophore Assembly Site Membrane Extrinsic Component Of Autophagosome Membrane Atg1/ULK1 Kinase Complex	Phagophore Assembly Site Mitochondrion Endoplasmic Reticulum Membrane Cytosol Extrinsic Component Of Membrane Atg1/ULK1 Kinase Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Rab GTPase Binding Identical Protein Binding Protein-containing Complex Binding GTPase Binding	Protein Binding Protein Kinase Regulator Activity Protein Kinase Binding
	Biological Process	Autophagosome Assembly Protein Phosphorylation Autophagy Signal Transduction Protein Localization Regulation Of Autophagy Positive Regulation Of Autophagy Macroautophagy Regulation Of Macroautophagy Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Neuron Projection Regeneration Neuron Projection Development Negative Regulation Of Protein Complex Assembly Cellular Response To Nutrient Levels Response To Starvation Protein Autophosphorylation Axon Extension Autophagy Of Host Cells Involved In Interaction With Symbiont Positive Regulation Of Autophagosome Assembly	Autophagosome Assembly Autophagy Of Mitochondrion Mitophagy Macroautophagy Regulation Of Macroautophagy Activation Of Protein Kinase Activity Protein Localization To Phagophore Assembly Site Piecemeal Microautophagy Of The Nucleus Autophagy Of Nucleus Response To Mitochondrial Depolarisation Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		Macroautophagy TBC/RABGAPs RAB GEFs exchange GTP for GDP on RABs Receptor Mediated Mitophagy	Macroautophagy
Drugs
Diseases
GWAS		Body mass index ( 26426971) Mercury levels ( 26025379)	Age at first sexual intercourse ( 27089180) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Headache ( 29397368) Immunoglobulin A ( 20694011) Reaction time ( 29844566) Schizophrenia ( 29483656) Selective IgA deficiency ( 27723758)
Interacting Genes		23 interacting genes: ATG13 ATG9A BECN1 EXOC8 GABARAP GABARAPL1 GABARAPL2 MAP1LC3A MAP1LC3B MAP1LC3C MAPK14 MBP MEFV MUL1 NEDD4L OCLN PPP1CA PRKAA1 SDCBP SMCR8 SYNGAP1 UBC USP20	12 interacting genes: APP ATG101 ATG14 GABARAP GABARAPL1 GABARAPL2 MAP1LC3A MAP1LC3B MAP1LC3C RB1CC1 SMCR8 ULK1
Entrez ID		8408	9776
HPRD ID		11933	13809
Ensembl ID		ENSG00000177169	ENSG00000175224
Uniprot IDs		O75385	A8K0S6 O75143
PDB IDs		4WNO 4WNP 5CI7 6HYO 6MNH 6QAS	3WAN 3WAO 3WAP 5C50 5XUY 5XV1 5XV3 5XV4 5XV6 6HYN
Enriched GO Terms of Interacting Partners?
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