MYD88 and TLR8

Number of citations of the paper that reports this interaction (PubMedID 16482509)
21

Data Source:
HPRD (two hybrid)

		MYD88	TLR8
Description		MYD88 innate immune signal transduction adaptor	toll like receptor 8
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Endosome Membrane	Golgi Membrane Endoplasmic Reticulum Membrane Plasma Membrane External Side Of Plasma Membrane Endosome Membrane Integral Component Of Membrane Endolysosome Membrane
	Molecular Function	Death Receptor Binding Protein Binding Toll-like Receptor Binding Identical Protein Binding Protein Self-association TIR Domain Binding	DNA Binding RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding Transmembrane Signaling Receptor Activity Drug Binding Signaling Receptor Activity Pattern Recognition Receptor Activity
	Biological Process	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Phagocytosis Apoptotic Process Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway Toll Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Type I Interferon Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-23 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Toll-like Receptor 9 Signaling Pathway Defense Response To Bacterium Defense Response To Protozoan Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Regulation Of Inflammatory Response Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Type I Interferon Signaling Pathway Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 3'-UTR-mediated MRNA Stabilization Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Positive Regulation Of Cytokine Production Involved In Inflammatory Response	Microglial Cell Activation Regulation Of Protein Phosphorylation Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Immune Response I-kappaB Kinase/NF-kappaB Signaling Response To Virus Immunoglobulin Mediated Immune Response Positive Regulation Of Interleukin-6 Production Toll-like Receptor 8 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Interferon-gamma Biosynthetic Process Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Interferon-alpha Biosynthetic Process Positive Regulation Of Interferon-beta Biosynthetic Process Positive Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Interleukin-1 Beta Secretion Defense Response To Virus Cellular Response To Mechanical Stimulus Positive Regulation Of Interleukin-6 Secretion Negative Regulation Of Interleukin-12 Secretion
Pathways		ER-Phagosome pathway PIP3 activates AKT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane RIP-mediated NFkB activation via ZBP1 p75NTR recruits signalling complexes p75NTR recruits signalling complexes DEx/H-box helicases activate type I IFN and inflammatory cytokines production MyD88 deficiency (TLR2/4) MyD88 deficiency (TLR5) IRAK4 deficiency (TLR5) IRAK4 deficiency (TLR2/4) PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Interleukin-1 signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 dependent cascade initiated on endosome MyD88 cascade initiated on plasma membrane	Trafficking and processing of endosomal TLR Toll Like Receptor 7/8 (TLR7/8) Cascade TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 dependent cascade initiated on endosome
Drugs			Imiquimod
Diseases
GWAS		Gut microbiota (bacterial taxa) ( 27723756) Mean corpuscular hemoglobin concentration ( 29403010)	Celiac disease ( 20190752)
Interacting Genes		40 interacting genes: BTK CD93 CISH FADD FLII IKBKG IL1R1 IL1RAP IL1RL1 IRAK1 IRAK2 IRAK3 IRAK4 IRF4 IRF5 IRF7 MAL MBIP MDM2 PELI2 PFKL POLR1C PRDX1 RAC1 SARM1 SIAH1 SIAH2 SMAD3 SPOP STAP2 TIRAP TLR10 TLR2 TLR3 TLR4 TLR5 TLR7 TLR8 TXN USP7	2 interacting genes: BTK MYD88
Entrez ID		4615	51311
HPRD ID		03703	02296
Ensembl ID		ENSG00000172936	ENSG00000101916
Uniprot IDs		A0A0A0MS70 A0A0A0MSI9 A0A3B3ITY3 A0A3F2YP85 H0Y4G9 Q99836	Q9NR97
PDB IDs		2JS7 2Z5V 3MOP 4DOM 4EO7 6I3N	3W3G 3W3J 3W3K 3W3L 3W3M 3W3N 3WN4 4QBZ 4QC0 4R07 4R08 4R09 4R0A 4R6A 5AWA 5AWB 5AWC 5AWD 5AZ5 5HDH 5WYX 5WYZ 5Z14 5Z15
Enriched GO Terms of Interacting Partners?
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