EOMES and PFDN1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		EOMES	PFDN1
Description		eomesodermin	prefoldin subunit 1
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus	Prefoldin Complex
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Sequence-specific DNA Binding	DNA-binding Transcription Factor Activity Protein Binding Protein Binding Involved In Protein Folding Unfolded Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Endoderm Formation Mesoderm Formation Cell Fate Specification Endodermal Cell Fate Specification Trophectodermal Cell Differentiation Heart Looping Adaptive Immune Response CD8-positive, Alpha-beta T Cell Differentiation Involved In Immune Response Brain Development Cardioblast Differentiation Stem Cell Population Maintenance Olfactory Bulb Development Cerebral Cortex Regionalization Cerebral Cortex Neuron Differentiation Interferon-gamma Production Skeletal Muscle Cell Differentiation Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Mesendoderm Development Cell Differentiation Involved In Embryonic Placenta Development Mesodermal To Mesenchymal Transition Involved In Gastrulation	Regulation Of Transcription, DNA-templated Protein Folding
Pathways			Prefoldin mediated transfer of substrate to CCT/TriC
Drugs
Diseases		Polymicrogyria; Bilateral frontal polymicrogyria (BFP); Bilateral frontoparietal polymicrogyria (BFPP); Bilateral perisylvian polymicrogyria (BPP); Bilateral parasagittal parieto-occipital polymicrogyria (BPOP); Bilateral generalised polymicrogyria (BGP); Unilateral Polymicrogyria (ULP)
GWAS		Ankylosing spondylitis ( 23749187) B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Chronic lymphocytic leukemia ( 28165464 26956414) Diastolic blood pressure ( 27841878) Epstein Barr virus nuclear antigen 1 IgG levels or multiple sclerosis ( 26819262) Hodgkin's lymphoma ( 24149102) Macular thickness ( 30535121) Mean arterial pressure ( 29403010) Multiple sclerosis ( 31604244 22190364 24076602 21833088) PR interval ( 30046033) Pulse pressure ( 29403010) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 24532676) Systemic lupus erythematosus ( 27399966) Systolic blood pressure ( 29403010)	Alzheimer's disease ( 28183528) Alzheimer's disease in APOE e4- carriers ( 25778476) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Reaction time ( 29844566)
Interacting Genes		1 interacting genes: PFDN1	53 interacting genes: ACTA1 ACTB ALB BRK1 CCDC85A CEP126 CHGA DCTN1 DEFA1 EDRF1 EIF3C EIF4A2 EOMES ESS2 EXT2 EZH2 FAM20C GET3 GIT1 GPRASP1 HAP1 HIP1 HMGXB3 HOXD8 IFT140 IMMT INPP5K JADE1 KIAA0408 LRIF1 MED31 NDC80 NR2F1 PDE4DIP PDHB PFDN2 PLXNB2 PRKD2 PSME1 PTN RMI1 RPLP1 RPS28 SEC31A SKP2 SNX5 SPTBN4 SUMO3 SYNDIG1 TERT TTC38 YEATS4 ZNF235
Entrez ID		8320	5201
HPRD ID		07054	05357
Ensembl ID		ENSG00000163508	ENSG00000113068
Uniprot IDs		B7Z4K0 O95936	O60925
PDB IDs			6NR8 6NR9 6NRB 6NRC 6NRD
Enriched GO Terms of Interacting Partners?
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