EOMES

Description		eomesodermin
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Endoderm Formation Mesoderm Formation Cell Fate Specification Endodermal Cell Fate Specification Trophectodermal Cell Differentiation Heart Looping Adaptive Immune Response CD8-positive, Alpha-beta T Cell Differentiation Involved In Immune Response Brain Development Cardioblast Differentiation Stem Cell Population Maintenance Olfactory Bulb Development Cerebral Cortex Regionalization Cerebral Cortex Neuron Differentiation Interferon-gamma Production Skeletal Muscle Cell Differentiation Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Mesendoderm Development Cell Differentiation Involved In Embryonic Placenta Development Mesodermal To Mesenchymal Transition Involved In Gastrulation
Pathways
Drugs
Diseases		Polymicrogyria; Bilateral frontal polymicrogyria (BFP); Bilateral frontoparietal polymicrogyria (BFPP); Bilateral perisylvian polymicrogyria (BPP); Bilateral parasagittal parieto-occipital polymicrogyria (BPOP); Bilateral generalised polymicrogyria (BGP); Unilateral Polymicrogyria (ULP)
GWAS		Ankylosing spondylitis ( 23749187) B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Chronic lymphocytic leukemia ( 28165464 26956414) Diastolic blood pressure ( 27841878) Epstein Barr virus nuclear antigen 1 IgG levels or multiple sclerosis ( 26819262) Hodgkin's lymphoma ( 24149102) Macular thickness ( 30535121) Mean arterial pressure ( 29403010) Multiple sclerosis ( 31604244 22190364 24076602 21833088) PR interval ( 30046033) Pulse pressure ( 29403010) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 24532676) Systemic lupus erythematosus ( 27399966) Systolic blood pressure ( 29403010)
Interacting Genes		1 interacting genes: PFDN1
Entrez ID		8320
HPRD ID		07054
Ensembl ID		ENSG00000163508
Uniprot IDs		B7Z4K0 O95936
PDB IDs
Enriched GO Terms of Interacting Partners?
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