SMC1A and NDC80

Number of citations of the paper that reports this interaction (PubMedID 9295362)
15

Data Source:
HPRD (two hybrid, in vitro)

		SMC1A	NDC80
Description		structural maintenance of chromosomes 1A	NDC80 kinetochore complex component
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome Nucleus Nucleoplasm Chromosome Cytosol Cohesin Complex Nuclear Matrix Meiotic Cohesin Complex Mitotic Spindle Pole	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome Kinetochore Condensed Nuclear Chromosome Outer Kinetochore Cell Nucleus Nucleoplasm Centrosome Cytosol Membrane Ndc80 Complex
	Molecular Function	Chromatin Binding RNA Binding Protein Binding ATP Binding Mediator Complex Binding Protein Heterodimerization Activity	Protein Binding Identical Protein Binding
	Biological Process	Mitotic Sister Chromatid Segregation DNA Repair Sister Chromatid Cohesion Mitotic Sister Chromatid Cohesion Response To Radiation Stem Cell Population Maintenance Cell Division Meiotic Cell Cycle Response To DNA Damage Checkpoint Signaling Regulation Of Mitotic Spindle Assembly	Mitotic Sister Chromatid Segregation Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Mitotic Spindle Organization Chromosome Segregation Attachment Of Spindle Microtubules To Kinetochore Cell Division Metaphase Plate Congression Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Organization Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Protein Localization To Kinetochore
Pathways		Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases		Cornelia de Lange syndrome (CdLS)
GWAS		Bipolar disorder ( 31043756)	Metabolite levels ( 23823483) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309)
Interacting Genes		17 interacting genes: ATM BLM BRCA1 ESR1 MCM6 MCM7 MDC1 MET MSH2 MSH6 NDC80 NUMA1 POLA1 RAD21 RFC1 RPGR SMC3	46 interacting genes: AMOTL2 ATF4 ATP5PO AURKA AURKB BLOC1S6 CALCOCO1 CCHCR1 CCNH CCNK CENPH CKAP5 HAUS1 HGS IFT20 INPP1 KLC3 KLHL12 KRT6B MAD1L1 MAD2L1 MFAP1 MIS12 NDE1 NDEL1 NEK2 NUF2 PCM1 PFDN1 PSMC2 RB1 RUFY4 SFR1 SGF29 SKA1 SMC1A SPC25 STX11 TFIP11 TNIP1 TOM1L1 TP53BP2 TXLNA USHBP1 WASHC3 ZWINT
Entrez ID		8243	10403
HPRD ID		02077	06277
Ensembl ID		ENSG00000072501	ENSG00000080986
Uniprot IDs		A0A384MR33 G8JLG1 Q14683 Q68EN4	A8K031 O14777
PDB IDs			2IGP 2VE7 3IZ0
Enriched GO Terms of Interacting Partners?
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