DOCK8 and FANCL

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		DOCK8	FANCL
Description		dedicator of cytokinesis 8	FA complementation group L
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Leading Edge Membrane Lamellipodium Membrane	Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Nuclear Body Intracellular Membrane-bounded Organelle Fanconi Anaemia Nuclear Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Immunological Synapse Formation Small GTPase Mediated Signal Transduction Blood Coagulation Dendritic Cell Migration Positive Regulation Of GTPase Activity Memory T Cell Proliferation Negative Regulation Of T Cell Apoptotic Process Positive Regulation Of Establishment Of T Cell Polarity Cellular Response To Chemokine Positive Regulation Of T Cell Migration	DNA Repair Protein Monoubiquitination Cellular Response To DNA Damage Stimulus Gamete Generation Interstrand Cross-link Repair Regulation Of Cell Proliferation
Pathways		Factors involved in megakaryocyte development and platelet production	Fanconi Anemia Pathway
Drugs
Diseases		Non-syndromic autosomal dominant mental retardation	Fanconi anemia
GWAS		Blond vs. brown/black hair color ( 30531825) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549) Mean platelet volume ( 22139419 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Nevus count ( 30429480) Nevus count or cutaneous melanoma ( 30429480) Obesity-related traits ( 23251661) Platelet count ( 27863252) Platelet distribution width ( 27863252) Post bronchodilator FEV1 ( 26634245) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252)	Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 31453325 20935630) Body mass index variance ( 31453325) Childhood absence epilepsy ( 30531953) Chronotype ( 30696823) Epilepsy ( 25087078 30531953) Feeling miserable ( 29500382) Generalized epilepsy ( 30531953) Hirschsprung disease ( 27702942) Initial pursuit acceleration ( 29064472) Irritable mood ( 29500382) Obesity ( 23563607) Pre-treatment viral load in HIV-1 infection ( 31219150) Response to selective serotonin reuptake inhibitors and depression ( 27622933) Schizophrenia ( 25056061 29483656) Smoking status (ever vs never smokers) ( 30643258) Tea consumption ( 31046077) Type 2 diabetes ( 30718926) Waist circumference ( 25673412) Waist-hip ratio ( 25673412)
Interacting Genes		24 interacting genes: BYSL CARHSP1 CDC42 CHMP2A DGCR6 EXOSC5 FAM124A FAM161A FANCL FBXL12 HBZ KRT40 MED30 MEOX2 MRPL38 MTG1 PIMREG RAC1 RHOJ RHOQ RTP5 SMAD2 ZFC3H1 ZNF581	26 interacting genes: ACVR1 BMPR1B CHCHD3 CTBP1 DOCK8 EIF4ENIF1 FAAP100 FANCB FANCD2 FANCF FANCI GGN GRN HES1 IHO1 IKZF3 KIFC3 LZTS2 PCNA RBM45 RIMBP3 SSX2IP TFCP2 TGFBR1 UBE2T UBE2W
Entrez ID		81704	55120
HPRD ID		10920	06997
Ensembl ID		ENSG00000107099	ENSG00000115392
Uniprot IDs		E2J6M5 E2J6M6 Q8NF50	Q9NW38
PDB IDs			3ZQS 4CCG
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?