DOCK8 and CARHSP1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		DOCK8	CARHSP1
Description		dedicator of cytokinesis 8	calcium regulated heat stable protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Leading Edge Membrane Lamellipodium Membrane	Cytoplasmic Exosome (RNase Complex) P-body Cytoplasm Cytosol P Granule
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific MRNA 3'-UTR Binding Protein Binding Phosphatase Binding
	Biological Process	Immunological Synapse Formation Small GTPase Mediated Signal Transduction Blood Coagulation Dendritic Cell Migration Positive Regulation Of GTPase Activity Memory T Cell Proliferation Negative Regulation Of T Cell Apoptotic Process Positive Regulation Of Establishment Of T Cell Polarity Cellular Response To Chemokine Positive Regulation Of T Cell Migration	Regulation Of Transcription By RNA Polymerase II Intracellular Signal Transduction Regulation Of MRNA Stability
Pathways		Factors involved in megakaryocyte development and platelet production
Drugs
Diseases		Non-syndromic autosomal dominant mental retardation
GWAS		Blond vs. brown/black hair color ( 30531825) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549) Mean platelet volume ( 22139419 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Nevus count ( 30429480) Nevus count or cutaneous melanoma ( 30429480) Obesity-related traits ( 23251661) Platelet count ( 27863252) Platelet distribution width ( 27863252) Post bronchodilator FEV1 ( 26634245) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252)	Intracranial aneurysm ( 29531279)
Interacting Genes		24 interacting genes: BYSL CARHSP1 CDC42 CHMP2A DGCR6 EXOSC5 FAM124A FAM161A FANCL FBXL12 HBZ KRT40 MED30 MEOX2 MRPL38 MTG1 PIMREG RAC1 RHOJ RHOQ RTP5 SMAD2 ZFC3H1 ZNF581	18 interacting genes: AKT1 DOCK8 KRTAP10-3 KRTAP10-7 KRTAP10-8 NOTCH2NLA PIAS3 PIN1 PNMA1 RPS6KA1 SGK1 SMN1 SRPK2 STC2 STYX TK1 TRAF1 TSC22D1
Entrez ID		81704	23589
HPRD ID		10920	08515
Ensembl ID		ENSG00000107099	ENSG00000153048
Uniprot IDs		E2J6M5 E2J6M6 Q8NF50	Q9Y2V2
PDB IDs			3AQQ
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
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