TSC22D4 and MAD2L1

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1016

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		TSC22D4	MAD2L1
Description		TSC22 domain family member 4	mitotic arrest deficient 2 like 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Kinetochore Condensed Chromosome Kinetochore Spindle Pole Cell Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Nuclear Pore Nuclear Basket Perinuclear Region Of Cytoplasm Mitotic Spindle
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding	Protein Binding Protein C-terminus Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Response To Osmotic Stress Negative Regulation Of Transcription, DNA-templated	Mitotic Sister Chromatid Segregation Establishment Of Mitotic Spindle Orientation Ubiquitin-dependent Protein Catabolic Process Mitotic Cell Cycle Checkpoint Mitotic Spindle Assembly Checkpoint Anaphase-promoting Complex-dependent Catabolic Process Negative Regulation Of Protein Catabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Mitotic Cell Cycle Cell Division Establishment Of Centrosome Localization Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Ubiquitin Protein Ligase Activity
Pathways			Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Cdc20:Phospho-APC/C mediated degradation of Cyclin A APC/C:Cdc20 mediated degradation of mitotic proteins APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Platelet count ( 27863252)	Coronary artery disease ( 28714974) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) F-cell distribution in sickle cell anaemia ( 21326311) HIV-1 viral setpoint ( 22174851) Loneliness (multivariate analysis) ( 27629369)
Interacting Genes		54 interacting genes: ABLIM1 AIFM1 APIP BLZF1 CCDC146 CCDC33 CCDC42 CCNK CDC23 CDK5R1 CKS2 CLU ENKD1 FBXW7 FRMD6 FXR2 GOLGA2 GORASP2 KPNA2 KRT40 LBP LMO2 LNX1 LRP2BP MAD2L1 MTHFS MYLIP NIF3L1 NOC4L NRBP1 NRBP2 PCBP1 PIH1D1 PIN1 POLR1C PPL PRKAA1 PRKAA2 PRNP PSMA1 RACK1 SACS SAT1 SMAD3 SMARCB1 SYT17 TEX11 TLE5 TSC22D1 TSPOAP1 UBLCP1 ZBTB24 ZMYND10 ZNF580	23 interacting genes: ADAM17 ANAPC2 APP CCNA2 CDC16 CDC20 CDC27 CSF2RB ESR2 H3C1 INSR KEAP1 MAD1L1 MAD2L1BP MAD2L2 MBL2 NDC80 RABAC1 REV3L SDCBP TRIP13 TSC22D4 UBD
Entrez ID		81628	4085
HPRD ID		18231	03274
Ensembl ID		ENSG00000166925	ENSG00000164109
Uniprot IDs		B4DKI8 Q9Y3Q8	Q13257
PDB IDs			1DUJ 1GO4 1KLQ 1S2H 2QYF 2V64 2VFX 3GMH 5KHU 5LCW 6F0X
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?