TSC22D4 and CDC23

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1016

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TSC22D4	CDC23
Description		TSC22 domain family member 4	cell division cycle 23
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Intracellular Cell Nucleoplasm Anaphase-promoting Complex Cytoplasm Cytosol
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Response To Osmotic Stress Negative Regulation Of Transcription, DNA-templated	Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Mitotic Metaphase Plate Congression Metaphase/anaphase Transition Of Mitotic Cell Cycle Regulation Of Exit From Mitosis Protein Ubiquitination Regulation Of Mitotic Metaphase/anaphase Transition Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Protein K11-linked Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition
Pathways			Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Platelet count ( 27863252)	Autism spectrum disorder or schizophrenia ( 28540026) Resting heart rate ( 27798624)
Interacting Genes		54 interacting genes: ABLIM1 AIFM1 APIP BLZF1 CCDC146 CCDC33 CCDC42 CCNK CDC23 CDK5R1 CKS2 CLU ENKD1 FBXW7 FRMD6 FXR2 GOLGA2 GORASP2 KPNA2 KRT40 LBP LMO2 LNX1 LRP2BP MAD2L1 MTHFS MYLIP NIF3L1 NOC4L NRBP1 NRBP2 PCBP1 PIH1D1 PIN1 POLR1C PPL PRKAA1 PRKAA2 PRNP PSMA1 RACK1 SACS SAT1 SMAD3 SMARCB1 SYT17 TEX11 TLE5 TSC22D1 TSPOAP1 UBLCP1 ZBTB24 ZMYND10 ZNF580	45 interacting genes: ANAPC10 APOL1 ATRIP BCAS3 BYSL CBY2 CCDC24 CDC16 CDT1 CEP44 COIL CRACR2A CTBP1 CYB5R2 DEPDC1B DLX6-AS1 EIF5A2 FAM9B FBXO5 GORASP2 HEMK1 IHO1 INCA1 INPP5J KCTD6 KDM1A LZTS2 MAPK3 OPTN PNMA5 RAC1 RAD54B RBM15B RBPMS RSL24D1 SIAH1 SLC52A2 SMARCB1 SMUG1 SOX5 SSX2IP SUV39H1 TRIM27 TSC22D4 UBE2S
Entrez ID		81628	8697
HPRD ID		18231	07221
Ensembl ID		ENSG00000166925	ENSG00000094880
Uniprot IDs		B4DKI8 Q9Y3Q8	Q9UJX2
PDB IDs			4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
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