NDEL1 and MLLT10

Number of citations of the paper that reports this interaction (PubMedID 17043677)
168

Data Source:
BioGRID (two hybrid)

		NDEL1	MLLT10
Description		nudE neurodevelopment protein 1 like 1	MLLT10 histone lysine methyltransferase DOT1L cofactor
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GO Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Cell Nuclear Envelope Centrosome Spindle Cytosol Kinesin Complex Microtubule Synaptic Vesicle Cell Leading Edge Axon Hillock Neurofilament Cytoskeleton Central Region Of Growth Cone Axon Cytoplasm	Nucleus Nucleoplasm Cytosol Protein-containing Complex
	Molecular Function	Protein Binding Microtubule Binding Identical Protein Binding Alpha-tubulin Binding Protein-containing Complex Binding Beta-tubulin Binding Oligopeptidase Activity	DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Nucleosome Binding Histone Binding Metal Ion Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Neuron Migration Inner Cell Mass Cell Proliferation Proteolysis Microtubule Nucleation Chromosome Segregation Mitotic Centrosome Separation Retrograde Axonal Transport Insulin Receptor Signaling Pathway Regulation Of Neuron Projection Development Cell Migration Cerebral Cortex Radially Oriented Cell Migration Central Nervous System Neuron Axonogenesis Lysosome Localization Regulation Of Intracellular Protein Transport Positive Regulation Of GTPase Activity Positive Regulation Of Axon Extension Vesicle Transport Along Microtubule Positive Regulation Of Axon Regeneration Nuclear Envelope Disassembly Establishment Of Chromosome Localization Centrosome Localization Neurofilament Cytoskeleton Organization Activation Of GTPase Activity Positive Regulation Of Ruffle Assembly Neuron Projection Extension Regulation Of Microtubule Motor Activity	Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS			Breast cancer ( 23535729) Epithelial ovarian cancer ( 25581431) Gallstone disease ( 30504769) Hand grip strength ( 29691431) Lateral ventricular volume in normal aging ( 30258056) Meningioma ( 21804547) Metabolic syndrome ( 31589552) Multiple sclerosis ( 31604244) Multisite chronic pain ( 31194737) Ovarian cancer ( 23535730) Subcutaneous adipose tissue ( 26480920) Urinary albumin-to-creatinine ratio ( 31630189) Urinary sodium excretion ( 31409800)
Interacting Genes		74 interacting genes: ACTB AIMP2 AKAP9 ANK2 APP BMI1 CASK CCDC88A CCSER1 CDK5 CENPF CEP170 CEP55 CEP63 CWF19L2 DISC1 DIXDC1 DTNB DYNC1H1 DYNC1I1 DYNLL1 FXR2 GOLGA2 IMMT KALRN KIF19 KIF2C KIF5A KIFC3 KLC4 KRT40 LUC7L2 MAGEA11 MBIP MIS18A MLLT10 MRC2 MTUS2 MYO5A NDC80 PAFAH1B1 PARD6G PKP2 PRC1 RBM10 RBM14 RBM5 RPA2 SLAIN1 SNAPC5 SNX6 SYNE1 TACC3 TRAF3IP3 TUBB USP2 XPA YWHAE YWHAG ZNF10 ZNF17 ZNF180 ZNF197 ZNF211 ZNF230 ZNF260 ZNF264 ZNF417 ZNF490 ZNF544 ZNF572 ZNF599 ZNF844 ZNF91	7 interacting genes: DISC1 DOT1L MLLT1 NDEL1 RGPD5 SS18 YEATS4
Entrez ID		81565	8028
HPRD ID		06340	03874
Ensembl ID		ENSG00000166579	ENSG00000078403
Uniprot IDs		A6NIZ0 Q9GZM8	P55197 Q59EQ6 Q6N002
PDB IDs		2V66	5DAG 5DAH 6CKN 6CKO 6JN2
Enriched GO Terms of Interacting Partners?
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