MLLT10 and MLLT1

Number of citations of the paper that reports this interaction (PubMedID 15856011)
39

Data Source:
BioGRID (affinity chromatography technology, two hybrid)
HPRD (two hybrid)

		MLLT10	MLLT1
Description		MLLT10 histone lysine methyltransferase DOT1L cofactor	MLLT1 super elongation complex subunit
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Protein-containing Complex	Fibrillar Center Nucleus Nucleoplasm Cytosol Transcription Elongation Factor Complex
	Molecular Function	DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Nucleosome Binding Histone Binding Metal Ion Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding
	Biological Process	Positive Regulation Of Transcription By RNA Polymerase II	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Negative Regulation Of Protein Kinase Activity
Pathways			Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation
Drugs
Diseases			Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS		Breast cancer ( 23535729) Epithelial ovarian cancer ( 25581431) Gallstone disease ( 30504769) Hand grip strength ( 29691431) Lateral ventricular volume in normal aging ( 30258056) Meningioma ( 21804547) Metabolic syndrome ( 31589552) Multiple sclerosis ( 31604244) Multisite chronic pain ( 31194737) Ovarian cancer ( 23535730) Subcutaneous adipose tissue ( 26480920) Urinary albumin-to-creatinine ratio ( 31630189) Urinary sodium excretion ( 31409800)	Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 27021288)
Interacting Genes		7 interacting genes: DISC1 DOT1L MLLT1 NDEL1 RGPD5 SS18 YEATS4	11 interacting genes: AFF1 AFF4 ALKBH4 ARID1A BMI1 CBX8 H1-5 H3-4 MLLT10 PAF1 WDR5
Entrez ID		8028	4298
HPRD ID		03874	15933
Ensembl ID		ENSG00000078403	ENSG00000130382
Uniprot IDs		P55197 Q59EQ6 Q6N002	Q03111
PDB IDs		5DAG 5DAH 6CKN 6CKO 6JN2	5J9S 6HPW 6HPX 6HPY 6HPZ 6HQ0 6HT0 6HT1 6T1I 6T1J 6T1L 6T1M 6T1N 6T1O
Enriched GO Terms of Interacting Partners?
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