NDEL1 and MYO5A

Number of citations of the paper that reports this interaction (PubMedID 30217970)
1

Data Source:
BioGRID (two hybrid)

		NDEL1	MYO5A
Description		nudE neurodevelopment protein 1 like 1	myosin VA
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GO Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Cell Nuclear Envelope Centrosome Spindle Cytosol Kinesin Complex Microtubule Synaptic Vesicle Cell Leading Edge Axon Hillock Neurofilament Cytoskeleton Central Region Of Growth Cone Axon Cytoplasm	Ruffle Photoreceptor Outer Segment Cell Cytoplasm Lysosome Early Endosome Late Endosome Peroxisome Endoplasmic Reticulum Smooth Endoplasmic Reticulum Golgi Apparatus Cytosol Intermediate Filament Actin Filament Actin Cytoskeleton Membrane Unconventional Myosin Complex Growth Cone Vesicle Filopodium Tip Insulin-responsive Compartment Microtubule Plus-end Melanosome Actomyosin Neuron Projection Neuronal Cell Body Recycling Endosome Extracellular Exosome Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding Microtubule Binding Identical Protein Binding Alpha-tubulin Binding Protein-containing Complex Binding Beta-tubulin Binding Oligopeptidase Activity	Microfilament Motor Activity RNA Binding Calcium Ion Binding Protein Binding Calmodulin Binding ATP Binding Rab GTPase Binding Actin-dependent ATPase Activity Identical Protein Binding Actin Filament Binding Disordered Domain Specific Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Neuron Migration Inner Cell Mass Cell Proliferation Proteolysis Microtubule Nucleation Chromosome Segregation Mitotic Centrosome Separation Retrograde Axonal Transport Insulin Receptor Signaling Pathway Regulation Of Neuron Projection Development Cell Migration Cerebral Cortex Radially Oriented Cell Migration Central Nervous System Neuron Axonogenesis Lysosome Localization Regulation Of Intracellular Protein Transport Positive Regulation Of GTPase Activity Positive Regulation Of Axon Extension Vesicle Transport Along Microtubule Positive Regulation Of Axon Regeneration Nuclear Envelope Disassembly Establishment Of Chromosome Localization Centrosome Localization Neurofilament Cytoskeleton Organization Activation Of GTPase Activity Positive Regulation Of Ruffle Assembly Neuron Projection Extension Regulation Of Microtubule Motor Activity	Exocytosis Post-Golgi Vesicle-mediated Transport Actin Filament Organization Chemical Synaptic Transmission Visual Perception Vesicle-mediated Transport Actin Filament-based Movement Vesicle Transport Along Actin Filament Insulin Secretion Melanocyte Differentiation Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Locomotion Involved In Locomotory Behavior Secretory Granule Localization Melanosome Transport Cellular Response To Insulin Stimulus Melanin Biosynthetic Process Odontogenesis Myelination Long-chain Fatty Acid Biosynthetic Process Hair Follicle Maturation Synapse Organization Protein Localization To Plasma Membrane Establishment Of Endoplasmic Reticulum Localization To Postsynapse Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Regulation Of Golgi Organization
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Translocation of SLC2A4 (GLUT4) to the plasma membrane Regulation of actin dynamics for phagocytic cup formation Insulin processing FCGR3A-mediated phagocytosis
Drugs
Diseases			Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS			Metabolite levels (Pyroglutamine) ( 23934736)
Interacting Genes		74 interacting genes: ACTB AIMP2 AKAP9 ANK2 APP BMI1 CASK CCDC88A CCSER1 CDK5 CENPF CEP170 CEP55 CEP63 CWF19L2 DISC1 DIXDC1 DTNB DYNC1H1 DYNC1I1 DYNLL1 FXR2 GOLGA2 IMMT KALRN KIF19 KIF2C KIF5A KIFC3 KLC4 KRT40 LUC7L2 MAGEA11 MBIP MIS18A MLLT10 MRC2 MTUS2 MYO5A NDC80 PAFAH1B1 PARD6G PKP2 PRC1 RBM10 RBM14 RBM5 RPA2 SLAIN1 SNAPC5 SNX6 SYNE1 TACC3 TRAF3IP3 TUBB USP2 XPA YWHAE YWHAG ZNF10 ZNF17 ZNF180 ZNF197 ZNF211 ZNF230 ZNF260 ZNF264 ZNF417 ZNF490 ZNF544 ZNF572 ZNF599 ZNF844 ZNF91	14 interacting genes: AKAP9 BMF CALM1 DLGAP1 DYNLL1 DYNLL2 MLPH NDEL1 NEFL PRPH RAB11A RAB27A TRIM2 TRIM3
Entrez ID		81565	4644
HPRD ID		06340	01179
Ensembl ID		ENSG00000166579	ENSG00000197535
Uniprot IDs		A6NIZ0 Q9GZM8	A8CDT9 Q9UES4 Q9Y4I1
PDB IDs		2V66	4D07 4J5L 4LLI 4LX1 4LX2 5JCY 5JCZ
Enriched GO Terms of Interacting Partners?
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