MLLT10 and DOT1L

Number of citations of the paper that reports this interaction (PubMedID 26496610)
285

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vivo)

		MLLT10	DOT1L
Description		MLLT10 histone lysine methyltransferase DOT1L cofactor	DOT1 like histone lysine methyltransferase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Protein-containing Complex	Chromosome, Telomeric Region Nucleus Nucleoplasm Protein-containing Complex Intracellular Membrane-bounded Organelle
	Molecular Function	DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Nucleosome Binding Histone Binding Metal Ion Binding	DNA Binding Protein Binding Histone-lysine N-methyltransferase Activity Histone Methyltransferase Activity (H3-K79 Specific) Histone Methyltransferase Activity
	Biological Process	Positive Regulation Of Transcription By RNA Polymerase II	DNA Damage Checkpoint DNA Repair Chromatin Silencing At Telomere Positive Regulation Of Cell Proliferation Telomere Organization Histone H3-K79 Methylation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of JAK-STAT Cascade Regulation Of Transcription Regulatory Region DNA Binding
Pathways			PKMTs methylate histone lysines
Drugs
Diseases
GWAS		Breast cancer ( 23535729) Epithelial ovarian cancer ( 25581431) Gallstone disease ( 30504769) Hand grip strength ( 29691431) Lateral ventricular volume in normal aging ( 30258056) Meningioma ( 21804547) Metabolic syndrome ( 31589552) Multiple sclerosis ( 31604244) Multisite chronic pain ( 31194737) Ovarian cancer ( 23535730) Subcutaneous adipose tissue ( 26480920) Urinary albumin-to-creatinine ratio ( 31630189) Urinary sodium excretion ( 31409800)	Heel bone mineral density ( 30598549 28869591) Height ( 28552196 20881960 25282103 23563607 18391950) Hematocrit ( 29403010) Hemoglobin ( 29403010) Hip circumference adjusted for BMI ( 25673412) Hip minimal joint space width ( 27701424) Myocardial infarction ( 24916648) Osteoarthritis ( 22566624) Pulse pressure ( 26390057 27841878 29403010 27618448 30487518 30578418) Red blood cell count ( 29403010) Systolic blood pressure ( 27618448 30487518)
Interacting Genes		7 interacting genes: DISC1 DOT1L MLLT1 NDEL1 RGPD5 SS18 YEATS4	4 interacting genes: H3-4 MLLT10 MYCN STAT1
Entrez ID		8028	84444
HPRD ID		03874	10455
Ensembl ID		ENSG00000078403	ENSG00000104885
Uniprot IDs		P55197 Q59EQ6 Q6N002	Q8TEK3
PDB IDs		5DAG 5DAH 6CKN 6CKO 6JN2	1NW3 2MV7 3QOW 3QOX 3SR4 3SX0 3UWP 4EK9 4EKG 4EKI 4EQZ 4ER0 4ER3 4ER5 4ER6 4ER7 4HRA 4WVL 5DRT 5DRY 5DSX 5DT2 5DTM 5DTQ 5DTR 5JUW 5MVS 5MW3 5MW4 6IN3 6J99 6JM9 6JMA 6JN2 6NJ9 6NN6 6NOG 6NQA 6O96
Enriched GO Terms of Interacting Partners?
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