SYNC and DES

Number of citations of the paper that reports this interaction (PubMedID 11694502)
23

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		SYNC	DES
Description		syncoilin, intermediate filament protein	desmin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament Z Disc Neuromuscular Junction Sarcolemma Perinuclear Region Of Cytoplasm	Nucleus Cytosol Intermediate Filament Fascia Adherens Intercalated Disc Z Disc Neuromuscular Junction Sarcolemma Intermediate Filament Cytoskeleton Extracellular Exosome Cardiac Myofibril
	Molecular Function		Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Identical Protein Binding
	Biological Process	Intermediate Filament-based Process	Muscle Contraction Cytoskeleton Organization Regulation Of Heart Contraction Muscle Filament Sliding Intermediate Filament Organization
Pathways			Striated Muscle Contraction
Drugs
Diseases			Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM) Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy Scapuloperoneal myopathy (SPM) Dilated cardiomyopathy (DCM)
GWAS			Resting heart rate ( 27798624)
Interacting Genes		2 interacting genes: DES DTNA	27 interacting genes: AURKB BRCA1 CAPN1 CRYAB DDX10 DSP EHHADH HSPB1 ITSN1 MAPKAPK2 NEB NEFL PKD1 PLEKHA5 PPP1R18 ROCK1 S100A1 S100B SHBG SPTAN1 SYNC SYNM TRIM55 TRIM63 TRIM7 UBE2I VIM
Entrez ID		81493	1674
HPRD ID		18134	00514
Ensembl ID		ENSG00000162520	ENSG00000175084
Uniprot IDs		Q9H7C4	P17661 Q53SB5
PDB IDs
Enriched GO Terms of Interacting Partners?
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