DES and SYNM

Number of citations of the paper that reports this interaction (PubMedID 11353857)
32

Data Source:
HPRD (in vitro)

		DES	SYNM
Description		desmin	synemin
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Intermediate Filament Fascia Adherens Intercalated Disc Z Disc Neuromuscular Junction Sarcolemma Intermediate Filament Cytoskeleton Extracellular Exosome Cardiac Myofibril	Intermediate Filament Adherens Junction Sarcolemma Costamere Intermediate Filament Cytoskeleton Neurofilament Cytoskeleton
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Identical Protein Binding	Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Muscle Vinculin Binding Intermediate Filament Binding
	Biological Process	Muscle Contraction Cytoskeleton Organization Regulation Of Heart Contraction Muscle Filament Sliding Intermediate Filament Organization	Fast-twitch Skeletal Muscle Fiber Contraction Intermediate Filament Cytoskeleton Organization
Pathways		Striated Muscle Contraction
Drugs
Diseases		Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM) Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy Scapuloperoneal myopathy (SPM) Dilated cardiomyopathy (DCM)
GWAS		Resting heart rate ( 27798624)	Carotid plaque burden ( 28282560) Low high density lipoprotein cholesterol levels ( 26879886)
Interacting Genes		27 interacting genes: AURKB BRCA1 CAPN1 CRYAB DDX10 DSP EHHADH HSPB1 ITSN1 MAPKAPK2 NEB NEFL PKD1 PLEKHA5 PPP1R18 ROCK1 S100A1 S100B SHBG SPTAN1 SYNC SYNM TRIM55 TRIM63 TRIM7 UBE2I VIM	4 interacting genes: DES DTNA PCSK6 SELENOS
Entrez ID		1674	23336
HPRD ID		00514	07305
Ensembl ID		ENSG00000175084	ENSG00000182253
Uniprot IDs		P17661 Q53SB5	A0A075B7B1 O15061
PDB IDs			6EWO
Enriched GO Terms of Interacting Partners?
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