DES and PLEKHA5

Number of citations of the paper that reports this interaction (PubMedID 20936779)
85

Data Source:
BioGRID (two hybrid)

		DES	PLEKHA5
Description		desmin	pleckstrin homology domain containing A5
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Intermediate Filament Fascia Adherens Intercalated Disc Z Disc Neuromuscular Junction Sarcolemma Intermediate Filament Cytoskeleton Extracellular Exosome Cardiac Myofibril	Nucleoplasm Cytosol Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Identical Protein Binding	Protein Binding Phosphatidylinositol-5-phosphate Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Muscle Contraction Cytoskeleton Organization Regulation Of Heart Contraction Muscle Filament Sliding Intermediate Filament Organization	Biological_process Reproductive System Development
Pathways		Striated Muscle Contraction	Synthesis of PIPs at the plasma membrane
Drugs
Diseases		Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM) Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy Scapuloperoneal myopathy (SPM) Dilated cardiomyopathy (DCM)
GWAS		Resting heart rate ( 27798624)	Chronic mountain sickness ( 31417607) Daytime sleep phenotypes ( 27126917) Gut microbiota (bacterial taxa) ( 27694959) Pharmacokinetics of antiepileptic drugs in severe mental disorder (concentration drug ratio) ( 25944848) Thalamus volume ( 31530798)
Interacting Genes		27 interacting genes: AURKB BRCA1 CAPN1 CRYAB DDX10 DSP EHHADH HSPB1 ITSN1 MAPKAPK2 NEB NEFL PKD1 PLEKHA5 PPP1R18 ROCK1 S100A1 S100B SHBG SPTAN1 SYNC SYNM TRIM55 TRIM63 TRIM7 UBE2I VIM	36 interacting genes: ADK ARHGEF9 BET1 BLOC1S6 CCDC186 CCDC88B CCDC92 CEP250 CEP350 DES EVPL EXTL3 H2AJ KANSL1 KIF3A KRT19 KRT20 KTN1 LAMB2 LSM4 MAX PDZD11 PLEC PLEKHA6 PPP1R13B PROM1 RECQL SH3BP5L SOGA1 SPIRE1 SPTAN1 SPTBN1 SRPK2 UPF1 WASH2P YWHAG
Entrez ID		1674	54477
HPRD ID		00514	09684
Ensembl ID		ENSG00000175084	ENSG00000052126
Uniprot IDs		P17661 Q53SB5	A0A024RAY7 Q9HAU0
PDB IDs			2DKP
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?