TET1 and DDX21

		TET1	DDX21
Description		tet methylcytosine dioxygenase 1	DExD-box helicase 21
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GO Annotations	Cellular Component	Nucleus	Nucleoplasm Nucleolus Mitochondrion Cytosol Membrane
	Molecular Function	DNA Binding Iron Ion Binding Zinc Ion Binding Methyl-CpG Binding Methylcytosine Dioxygenase Activity	RNA Binding RNA Helicase Activity Double-stranded RNA Binding Protein Binding ATP Binding RRNA Binding SnoRNA Binding MiRNA Binding Identical Protein Binding 7SK SnRNA Binding
	Biological Process	Inner Cell Mass Cell Differentiation 5-methylcytosine Catabolic Process Chromatin Organization Protein O-linked Glycosylation Positive Regulation Of Cell Proliferation Stem Cell Population Maintenance Positive Regulation Of Histone Methylation Positive Regulation Of Transcription By RNA Polymerase II Oxidative Demethylation DNA Demethylation Negative Regulation Of Methylation-dependent Chromatin Silencing	Osteoblast Differentiation Positive Regulation Of Myeloid Dendritic Cell Cytokine Production RRNA Processing Transcription By RNA Polymerase II Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of Gene Expression, Epigenetic Defense Response To Virus
Pathways		TET1,2,3 and TDG demethylate DNA	B-WICH complex positively regulates rRNA expression Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Chronotype ( 30696823) Height ( 31562340) Pulse pressure ( 30224653) Triglycerides ( 30275531)	Depression (quantitative trait) ( 20800221)
Interacting Genes		2 interacting genes: DDX21 MBD3	18 interacting genes: ADAMTS14 CALM1 CSNK2A1 ERG H2AX IL7R JUN KPNA3 MTHFR PIAS1 PNMA2 SGPL1 SRPK2 SUMO2 TERF1 TERF2 TET1 UBE2I
Entrez ID		80312	9188
HPRD ID		09694	05895
Ensembl ID		ENSG00000138336	ENSG00000165732
Uniprot IDs		Q8NFU7	Q9NR30
PDB IDs		6ASD	2M3D
Enriched GO Terms of Interacting Partners?
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