DDX21 and TERF2

Number of citations of the paper that reports this interaction (PubMedID 21044950)
41

Data Source:
BioGRID (two hybrid)

		DDX21	TERF2
Description		DExD-box helicase 21	telomeric repeat binding factor 2
Image
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Mitochondrion Cytosol Membrane	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Nuclear Body Mre11 Complex Shelterin Complex Axon Cytoplasm
	Molecular Function	RNA Binding RNA Helicase Activity Double-stranded RNA Binding Protein Binding ATP Binding RRNA Binding SnoRNA Binding MiRNA Binding Identical Protein Binding 7SK SnRNA Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Double-stranded Telomeric DNA Binding Telomerase Activity Protein Binding Protein C-terminus Binding Enzyme Binding Telomeric DNA Binding Protein Homodimerization Activity Protein-containing Complex Binding G-rich Strand Telomeric DNA Binding
	Biological Process	Osteoblast Differentiation Positive Regulation Of Myeloid Dendritic Cell Cytokine Production RRNA Processing Transcription By RNA Polymerase II Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of Gene Expression, Epigenetic Defense Response To Virus	Telomere Maintenance RNA-dependent DNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Cell Cycle Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Telomere Capping Telomeric Loop Formation Protection From Non-homologous End Joining At Telomere Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Recombination Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of Nitric-oxide Synthase Activity Telomeric D-loop Disassembly Protein Localization To Chromosome, Telomeric Region Cellular Senescence Anterograde Axonal Transport Of Messenger Ribonucleoprotein Complex Negative Regulation Of Beta-galactosidase Activity Negative Regulation Of Telomere Single Strand Break Repair Negative Regulation Of Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of T-circle Formation Negative Regulation Of Exonuclease Activity Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Cellular Senescence
Pathways		B-WICH complex positively regulates rRNA expression Major pathway of rRNA processing in the nucleolus and cytosol	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase DNA Damage/Telomere Stress Induced Senescence
Drugs
Diseases
GWAS		Depression (quantitative trait) ( 20800221)	Body mass index ( 26426971) Logical memory (delayed recall) in normal cognition ( 29274321) Pulse pressure ( 30578418)
Interacting Genes		18 interacting genes: ADAMTS14 CALM1 CSNK2A1 ERG H2AX IL7R JUN KPNA3 MTHFR PIAS1 PNMA2 SGPL1 SRPK2 SUMO2 TERF1 TERF2 TET1 UBE2I	59 interacting genes: AFAP1L2 ANXA5 APEX1 ASS1 ATM BANP BARD1 BLM CCDC137 CTBP1 DDX21 DDX24 EP300 GNMT H2AX HDGFL2 HEXIM1 HEXIM2 HMGB1 HMGN1 HMGN2 HMGN3 HMGN4 LANCL2 LYAR MAGOHB NAIF1 NASP NCL NUMA1 NUMB NUTF2 NXNL1 OCM2 ORC3 ORC6 PIAS1 PIK3R3 PPM1G PRMT1 PTMA RNF113A RNF4 RPL13 RPRD1B SET SIAH1 SP100 SRSF6 TALDO1 TERF2IP TINF2 TMSB10 TOR1AIP1 UBE2I WDR4 WRN XRCC6 ZC3H18
Entrez ID		9188	7014
HPRD ID		05895	03610
Ensembl ID		ENSG00000165732	ENSG00000132604
Uniprot IDs		Q9NR30	Q15554
PDB IDs		2M3D	1H6P 1VF9 1VFC 1W0U 1XG1 3BU8 3BUA 3K6G 3SJM 4M7C 4RQI 5WQD 5XYF 6J67
Enriched GO Terms of Interacting Partners?
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