TET1 and MBD3

Number of citations of the paper that reports this interaction (PubMedID 22196727)
203

Data Source:
BioGRID (pull down)

		TET1	MBD3
Description		tet methylcytosine dioxygenase 1	methyl-CpG binding domain protein 3
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GO Annotations	Cellular Component	Nucleus	Nuclear Chromatin Heterochromatin Nucleus Nucleoplasm Cytoplasm NuRD Complex Protein-containing Complex
	Molecular Function	DNA Binding Iron Ion Binding Zinc Ion Binding Methyl-CpG Binding Methylcytosine Dioxygenase Activity	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA Binding Protein Binding Methyl-CpG Binding Nucleosomal DNA Binding
	Biological Process	Inner Cell Mass Cell Differentiation 5-methylcytosine Catabolic Process Chromatin Organization Protein O-linked Glycosylation Positive Regulation Of Cell Proliferation Stem Cell Population Maintenance Positive Regulation Of Histone Methylation Positive Regulation Of Transcription By RNA Polymerase II Oxidative Demethylation DNA Demethylation Negative Regulation Of Methylation-dependent Chromatin Silencing	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Methylation-dependent Chromatin Silencing Brain Development Heart Development Aging Tissue Development Histone Acetylation Response To Nutrient Levels Response To Estradiol ATP-dependent Chromatin Remodeling Regulation Of DNA Methylation Embryonic Organ Development Regulation Of Signal Transduction By P53 Class Mediator
Pathways		TET1,2,3 and TDG demethylate DNA	HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases
GWAS		Chronotype ( 30696823) Height ( 31562340) Pulse pressure ( 30224653) Triglycerides ( 30275531)
Interacting Genes		2 interacting genes: DDX21 MBD3	29 interacting genes: ATF7 AURKA BCL11B CEP76 GATAD2A GATAD2B GOLGA2 H3-4 HDAC1 ICA1 JUN KDM1A KDM5B KRT15 MBD2 MBD3L1 MBD3L2 MECOM MTA2 RBBP4 RBBP7 RCN3 SDCBP SMARCA4 SPEN TET1 TRIM54 ZBTB7A ZNF277
Entrez ID		80312	53615
HPRD ID		09694	04653
Ensembl ID		ENSG00000138336	ENSG00000071655
Uniprot IDs		Q8NFU7	O95983
PDB IDs		6ASD	2MB7 6CC8 6CCG 6CEU 6CEV
Enriched GO Terms of Interacting Partners?
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