DDX21 and SGPL1

		DDX21	SGPL1
Description		DExD-box helicase 21	sphingosine-1-phosphate lyase 1
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GO Annotations	Cellular Component	Nucleoplasm Nucleolus Mitochondrion Cytosol Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	RNA Binding RNA Helicase Activity Double-stranded RNA Binding Protein Binding ATP Binding RRNA Binding SnoRNA Binding MiRNA Binding Identical Protein Binding 7SK SnRNA Binding	Protein Binding Sphinganine-1-phosphate Aldolase Activity Carboxy-lyase Activity Pyridoxal Phosphate Binding
	Biological Process	Osteoblast Differentiation Positive Regulation Of Myeloid Dendritic Cell Cytokine Production RRNA Processing Transcription By RNA Polymerase II Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of Gene Expression, Epigenetic Defense Response To Virus	Luteinization Vasculogenesis Ameboidal-type Cell Migration Kidney Development Fatty Acid Metabolic Process Sphingolipid Metabolic Process Ceramide Metabolic Process Spermatogenesis Androgen Metabolic Process Estrogen Metabolic Process Post-embryonic Development Fibroblast Migration Hemopoiesis Sphingolipid Biosynthetic Process Sphingolipid Catabolic Process Leydig Cell Differentiation Regulation Of Multicellular Organism Growth Platelet-derived Growth Factor Receptor Signaling Pathway Skeletal System Morphogenesis Roof Of Mouth Development Face Morphogenesis Apoptotic Signaling Pathway
Pathways		B-WICH complex positively regulates rRNA expression Major pathway of rRNA processing in the nucleolus and cytosol	Sphingolipid de novo biosynthesis
Drugs			Pyridoxal Phosphate
Diseases
GWAS		Depression (quantitative trait) ( 20800221)	Metabolite levels ( 23823483) Microalbuminuria ( 26631737)
Interacting Genes		18 interacting genes: ADAMTS14 CALM1 CSNK2A1 ERG H2AX IL7R JUN KPNA3 MTHFR PIAS1 PNMA2 SGPL1 SRPK2 SUMO2 TERF1 TERF2 TET1 UBE2I	3 interacting genes: DDX21 SRPK2 STING1
Entrez ID		9188	8879
HPRD ID		05895	07224
Ensembl ID		ENSG00000165732	ENSG00000166224
Uniprot IDs		Q9NR30	O95470
PDB IDs		2M3D	4Q6R
Enriched GO Terms of Interacting Partners?
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