MAFK and NFE2

Number of citations of the paper that reports this interaction (PubMedID 8355703)
48

Data Source:
HPRD (in vivo, in vitro)

		MAFK	NFE2
Description		MAF bZIP transcription factor K	nuclear factor, erythroid 2
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm PML Body Protein-DNA Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Cofactor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding RING-like Zinc Finger Domain Binding	Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Proximal Promoter Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Sequence-specific DNA Binding Protein N-terminus Binding WW Domain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Nervous System Development Blood Coagulation	Nucleosome Disassembly Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Blood Coagulation Hemostasis Blood Circulation Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription, DNA-templated
Pathways		Factors involved in megakaryocyte development and platelet production Factors involved in megakaryocyte development and platelet production	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Factors involved in megakaryocyte development and platelet production Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS			Chronotype ( 30696823) Mean platelet volume ( 22139419 24026423) Platelet count ( 29403010 27863252) Plateletcrit ( 27863252) Red cell distribution width ( 28957414) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		11 interacting genes: BACH1 BACH2 DNMT3L HIF1A HOXD12 KAT6A MARS1 NFE2 NFE2L1 NFE2L2 NFE2L3	22 interacting genes: ATF4 BTRC CREBBP ELF5 HMGN1 ITCH KAT2B MAFF MAFG MAFK MAPK8 NEDD4 NFE2L2 NFE2L3 PEX14 PHYHIP PRIM1 SCAND1 SSX5 TXN WWP1 YAP1
Entrez ID		7975	4778
HPRD ID		02561	09030
Ensembl ID		ENSG00000198517	ENSG00000123405
Uniprot IDs		A0A024R804 O60675	A8K3E0 Q16621
PDB IDs			1LVX 2KZ5
Enriched GO Terms of Interacting Partners?
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