MAFK and BACH2

Number of citations of the paper that reports this interaction (PubMedID 8887638)
166

Data Source:
HPRD (in vitro, two hybrid)

		MAFK	BACH2
Description		MAF bZIP transcription factor K	BTB domain and CNC homolog 2
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm	Nuclear Chromatin Nucleus Nucleoplasm Cytosol
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Cofactor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding RING-like Zinc Finger Domain Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Nervous System Development Blood Coagulation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Import Into Nucleus Primary Adaptive Immune Response Involving T Cells And B Cells
Pathways		Factors involved in megakaryocyte development and platelet production Factors involved in megakaryocyte development and platelet production
Drugs
Diseases			Type I diabetes mellitus
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Ankylosing spondylitis ( 23749187) Asthma ( 31361310 30929738 27182965 31619474 29273806) Asthma (adult onset) ( 31036433 30929738) Asthma (childhood onset) ( 31036433 30929738) Asthma (moderate or severe) ( 30552067) Asthma onset (childhood vs adult) ( 30929738) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Basal cell carcinoma ( 31174203) Celiac disease ( 22057235 20190752 24999842) Celiac disease and Rheumatoid arthritis ( 26546613) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Cognitive performance ( 20125193) Crohn's disease ( 28067908 21102463) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) General risk tolerance (MTAG) ( 30643258) Graves' disease ( 21841780 22922229) Height ( 28552196) Hip circumference adjusted for BMI ( 28552196) Hypothyroidism ( 27182965) IgG glycosylation ( 23382691) Inflammatory bowel disease ( 28067908) Interleukin-6 levels ( 22205395) Keratinocyte cancer (MTAG) ( 31174203) Latent autoimmune diabetes ( 30254083) Lymphocyte counts ( 27863252) Mean corpuscular volume ( 27863252) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Medication use (thyroid preparations) ( 31015401) Monocyte percentage of white cells ( 27863252) Mosquito bite size ( 28199695) Multiple sclerosis ( 31604244 24076602 21833088) Nasal polyps ( 30643255) Neutrophil percentage of granulocytes ( 27863252) Obesity-related traits ( 23251661) Primary central nervous system lymphoma ( 31102405) Primary sclerosing cholangitis ( 23603763 27992413) Response to anti-TNF therapy in rheumatoid arthritis ( 26776603) Rheumatoid arthritis ( 23143596) Serum urate levels in chronic kidney disease ( 30181573) Squamous cell carcinoma ( 31174203) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 23273568) Thyroid peroxidase antibody positivity ( 24586183) Thyroid peroxidase autoantibody levels in type 1 diabetes ( 21829393) Type 1 diabetes ( 21829393 25751624 19430480 18840781 18978792) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Vitiligo ( 27723757 22561518) White blood cell count ( 27863252)
Interacting Genes		11 interacting genes: BACH1 BACH2 DNMT3L HIF1A HOXD12 KAT6A MARS1 NFE2 NFE2L1 NFE2L2 NFE2L3	8 interacting genes: BATF3 DDIT3 MAFF MAFG MAFK NFE2L1 NFE2L3 PATZ1
Entrez ID		7975	60468
HPRD ID		02561	12012
Ensembl ID		ENSG00000198517	ENSG00000112182
Uniprot IDs		A0A024R804 O60675	Q9BYV9
PDB IDs			3OHU 3OHV
Enriched GO Terms of Interacting Partners?
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