PDZD3 and GUCY2C

Number of citations of the paper that reports this interaction (PubMedID 11950846)
19

Data Source:
BioGRID (pull down, affinity chromatography technology)
HPRD (in vitro, in vivo, two hybrid)

		PDZD3	GUCY2C
Description		PDZ domain containing 3	guanylate cyclase 2C
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Brush Border Apical Junction Complex Apical Part Of Cell	Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Protein C-terminus Binding Ion Channel Inhibitor Activity Guanylate Cyclase Inhibitor Activity Ubiquitin-specific Protease Binding	Peptide Receptor Activity Guanylate Cyclase Activity Protein Kinase Activity Protein Binding ATP Binding GTP Binding Toxic Substance Binding Natriuretic Peptide Receptor Activity Peptide Hormone Binding
	Biological Process	Ion Transport Water Transport Receptor Guanylyl Cyclase Signaling Pathway Response To Toxic Substance Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of Guanylate Cyclase Activity	CGMP Biosynthetic Process Protein Phosphorylation Signal Transduction Receptor Guanylyl Cyclase Signaling Pathway Digestion Response To Toxic Substance Intracellular Signal Transduction Regulation Of Cell Proliferation
Pathways		Intestinal infectious diseases	Digestion Intestinal infectious diseases
Drugs			Linaclotide
Diseases
GWAS
Interacting Genes		18 interacting genes: ABCC2 ASAP3 CACNA1S CFTR GUCY2C NLRX1 PTGIR SLC15A1 SLC15A2 SLC22A3 SLC22A4 SLC22A5 SLC22A9 SLC41A3 SLCO1A2 SLCO1C1 SLCO3A1 SPRYD7	3 interacting genes: GUCA2A PDZD3 SRC
Entrez ID		79849	2984
HPRD ID		06191	07529
Ensembl ID		ENSG00000172367	ENSG00000070019
Uniprot IDs		B0YJ61 Q86UT5	P25092
PDB IDs		2V90
Enriched GO Terms of Interacting Partners?
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