PDZD3 and ABCC2

Number of citations of the paper that reports this interaction (PubMedID 12615054)
22

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		PDZD3	ABCC2
Description		PDZ domain containing 3	ATP binding cassette subfamily C member 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Brush Border Apical Junction Complex Apical Part Of Cell	Cell Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Brush Border Membrane Intercellular Canaliculus
	Molecular Function	Protein Binding Protein C-terminus Binding Ion Channel Inhibitor Activity Guanylate Cyclase Inhibitor Activity Ubiquitin-specific Protease Binding	Protein Binding ATP Binding Organic Anion Transmembrane Transporter Activity Xenobiotic Transmembrane Transporting ATPase Activity Bilirubin Transmembrane Transporter Activity ATPase Activity Protein Domain Specific Binding ATPase Activity, Coupled To Transmembrane Movement Of Substances Xenobiotic Transmembrane Transporter Activity
	Biological Process	Ion Transport Water Transport Receptor Guanylyl Cyclase Signaling Pathway Response To Toxic Substance Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of Guanylate Cyclase Activity	Response To Oxidative Stress Female Pregnancy Response To Heat Negative Regulation Of Gene Expression Mercury Ion Transport Bile Acid And Bile Salt Transport Canalicular Bile Acid Transport Bilirubin Transport Prostaglandin Transport Cellular Chloride Ion Homeostasis Response To Methotrexate Response To Estradiol Response To Glucagon Xenobiotic Catabolic Process Response To Estrogen Response To Arsenic-containing Substance Transmembrane Transport Thyroid Hormone Transport Transepithelial Transport Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Dexamethasone Stimulus Leukotriene Transport Benzylpenicillin Metabolic Process Drug Transmembrane Export Drug Transport Across Blood-brain Barrier
Pathways		Intestinal infectious diseases	Heme degradation ABC-family proteins mediated transport Defective ABCC2 causes Dubin-Johnson syndrome
Drugs			ATP Sulfinpyrazone
Diseases			Hyperbilirubinemia; Crigler-Najjar syndrome, type I (CN1); Crigler-Najjar syndrome, type II (CN2); Gilbert Syndrome; Dubin-Johnson syndrome (DJS)
GWAS			Carboplatin disposition in epthelial ovarian cancer ( 29367611) Colorectal cancer ( 26151821 24737748)
Interacting Genes		18 interacting genes: ABCC2 ASAP3 CACNA1S CFTR GUCY2C NLRX1 PTGIR SLC15A1 SLC15A2 SLC22A3 SLC22A4 SLC22A5 SLC22A9 SLC41A3 SLCO1A2 SLCO1C1 SLCO3A1 SPRYD7	12 interacting genes: AZIN1 CANX HSPA4 MCPH1 NFKB1 PDZD3 PDZK1 RDX SHANK3 SLC9A3R1 TUBB3 UBQLN1
Entrez ID		79849	1244
HPRD ID		06191	03065
Ensembl ID		ENSG00000172367	ENSG00000023839
Uniprot IDs		B0YJ61 Q86UT5	Q92887
PDB IDs		2V90
Enriched GO Terms of Interacting Partners?
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