TRIM25 and PITX2

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (pull down, two hybrid)

		TRIM25	PITX2
Description		tripartite motif containing 25	paired like homeodomain 2
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GO Annotations	Cellular Component	Nucleoplasm Cytosol Cytoplasmic Stress Granule Nuclear Body	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex
	Molecular Function	RNA Binding Protein Binding Ligase Activity RIG-I Binding Cadherin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Viral Process Translesion Synthesis Ubiquitin-dependent ERAD Pathway Negative Regulation Of Type I Interferon Production Response To Vitamin D RIG-I Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Estrogen Innate Immune Response Regulation Of Viral Entry Into Host Cell Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Interferon-gamma-mediated Signaling Pathway Regulation Of Viral Release From Host Cell Negative Regulation Of Viral Release From Host Cell Cellular Response To Leukemia Inhibitory Factor	Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Regulation Of Transcription By RNA Polymerase II Determination Of Left/right Symmetry Anatomical Structure Morphogenesis Hair Cell Differentiation Deltoid Tuberosity Development Odontogenesis Camera-type Eye Development Positive Regulation Of Transcription By RNA Polymerase II Spleen Development Somatotropin Secreting Cell Differentiation Prolactin Secreting Cell Differentiation Iris Morphogenesis Cell Proliferation Involved In Outflow Tract Morphogenesis Left/right Axis Specification
Pathways		ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Termination of translesion DNA synthesis Ovarian tumor domain proteases Interferon gamma signaling TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling	TFAP2 (AP-2) family regulates transcription of other transcription factors
Drugs
Diseases			Axenfeld-Rieger syndrome (ARS)
GWAS		Height ( 18391951) Lean body mass ( 28552196)	Appendicitis ( 30392061) Atrial fibrillation ( 28416818 28416822 29290336 30061737 29892015 20173747 19597492 22544366) Atrial fibrillation/atrial flutter ( 17603472) Cognitive decline rate in late mild cognitive impairment ( 26252872) Early onset atrial fibrillation ( 28460022) Heart failure ( 31919418) Incident atrial fibrillation ( 28416818) Intraocular pressure ( 29235454) Ischemic stroke ( 24262325 26708676 29531354) Ischemic stroke (cardioembolic) ( 27068588 26708676 29531354) Lung cancer ( 28604730) Prevalent atrial fibrillation ( 28416818) Smoking status (heavy vs never) ( 26423011) Stroke ( 29531354) Stroke (ischemic) ( 23041239)
Interacting Genes		36 interacting genes: AMFR APC ERCC2 ERG ESR1 GATA1 GRIK2 MAP3K13 MEIS2 MTA1 OTUB2 PAX2 PITX2 PLAAT4 RBCK1 RNF31 SFN STK11 STK38 TFG TRAF6 TRIM8 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2J2 UBE2L3 UBE2L6 UBE2N UBE2V1 USP15 USP39 ZC3HAV1 ZNF24	9 interacting genes: CTNNB1 HDAC1 HERC5 KAT5 LEF1 PDLIM1 PROP1 TRIM25 ZNHIT3
Entrez ID		7706	5308
HPRD ID		02711	03328
Ensembl ID		ENSG00000121060	ENSG00000164093
Uniprot IDs		Q14258	Q99697
PDB IDs		4CFG 4LTB 5EYA 5FER 5NT1 5NT2 6FLM 6FLN	2L7F 2L7M 2LKX
Enriched GO Terms of Interacting Partners?
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