TRIM25 and ZC3HAV1

Number of citations of the paper that reports this interaction (PubMedID 28202764)
15

Data Source:
BioGRID (affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study)

		TRIM25	ZC3HAV1
Description		tripartite motif containing 25	zinc finger CCCH-type containing, antiviral 1
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GO Annotations	Cellular Component	Nucleoplasm Cytosol Cytoplasmic Stress Granule Nuclear Body	Nucleus Cytosol
	Molecular Function	RNA Binding Protein Binding Ligase Activity RIG-I Binding Cadherin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	RNA Binding NAD+ ADP-ribosyltransferase Activity Protein Binding Cadherin Binding Metal Ion Binding NAD+ Binding Protein ADP-ribosylase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Viral Process Translesion Synthesis Ubiquitin-dependent ERAD Pathway Negative Regulation Of Type I Interferon Production Response To Vitamin D RIG-I Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Estrogen Innate Immune Response Regulation Of Viral Entry Into Host Cell Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Interferon-gamma-mediated Signaling Pathway Regulation Of Viral Release From Host Cell Negative Regulation Of Viral Release From Host Cell Cellular Response To Leukemia Inhibitory Factor	Protein ADP-ribosylation Response To Virus Negative Regulation Of Viral Genome Replication Innate Immune Response Defense Response To Virus Positive Regulation Of MRNA Catabolic Process Protein Poly-ADP-ribosylation
Pathways		ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Termination of translesion DNA synthesis Ovarian tumor domain proteases Interferon gamma signaling TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling	Signaling by BRAF and RAF fusions
Drugs
Diseases
GWAS		Height ( 18391951) Lean body mass ( 28552196)	Multiple sclerosis ( 31604244)
Interacting Genes		36 interacting genes: AMFR APC ERCC2 ERG ESR1 GATA1 GRIK2 MAP3K13 MEIS2 MTA1 OTUB2 PAX2 PITX2 PLAAT4 RBCK1 RNF31 SFN STK11 STK38 TFG TRAF6 TRIM8 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2J2 UBE2L3 UBE2L6 UBE2N UBE2V1 USP15 USP39 ZC3HAV1 ZNF24	2 interacting genes: APP TRIM25
Entrez ID		7706	56829
HPRD ID		02711	09534
Ensembl ID		ENSG00000121060	ENSG00000105939
Uniprot IDs		Q14258	Q7Z2W4
PDB IDs		4CFG 4LTB 5EYA 5FER 5NT1 5NT2 6FLM 6FLN	2X5Y 4X52 6UEI 6UEJ
Enriched GO Terms of Interacting Partners?
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