PITX2 and PDLIM1

Number of citations of the paper that reports this interaction (PubMedID 12464179)
181

Data Source:
HPRD (in vivo)

		PITX2	PDLIM1
Description		paired like homeodomain 2	PDZ and LIM domain 1
Image
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex	Stress Fiber Transcription Factor Complex Adherens Junction Focal Adhesion Z Disc Filamentous Actin
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding	Transcription Coactivator Activity Actin Binding Protein Binding Metal Ion Binding Muscle Alpha-actinin Binding Cadherin Binding Involved In Cell-cell Adhesion
	Biological Process	Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Regulation Of Transcription By RNA Polymerase II Determination Of Left/right Symmetry Anatomical Structure Morphogenesis Hair Cell Differentiation Deltoid Tuberosity Development Odontogenesis Camera-type Eye Development Positive Regulation Of Transcription By RNA Polymerase II Spleen Development Somatotropin Secreting Cell Differentiation Prolactin Secreting Cell Differentiation Iris Morphogenesis Cell Proliferation Involved In Outflow Tract Morphogenesis Left/right Axis Specification	Response To Hypoxia Regulation Of Transcription By RNA Polymerase II Response To Oxidative Stress Heart Development Actin Cytoskeleton Organization Muscle Structure Development Cell-cell Adhesion Positive Regulation Of Nucleic Acid-templated Transcription
Pathways		TFAP2 (AP-2) family regulates transcription of other transcription factors
Drugs
Diseases		Axenfeld-Rieger syndrome (ARS)
GWAS		Appendicitis ( 30392061) Atrial fibrillation ( 28416818 28416822 29290336 30061737 29892015 20173747 19597492 22544366) Atrial fibrillation/atrial flutter ( 17603472) Cognitive decline rate in late mild cognitive impairment ( 26252872) Early onset atrial fibrillation ( 28460022) Heart failure ( 31919418) Incident atrial fibrillation ( 28416818) Intraocular pressure ( 29235454) Ischemic stroke ( 24262325 26708676 29531354) Ischemic stroke (cardioembolic) ( 27068588 26708676 29531354) Lung cancer ( 28604730) Prevalent atrial fibrillation ( 28416818) Smoking status (heavy vs never) ( 26423011) Stroke ( 29531354) Stroke (ischemic) ( 23041239)	Mean platelet volume ( 27863252) Suicide risk ( 21041247)
Interacting Genes		9 interacting genes: CTNNB1 HDAC1 HERC5 KAT5 LEF1 PDLIM1 PROP1 TRIM25 ZNHIT3	13 interacting genes: ACTN1 ACTN2 ACTN4 AGK GFAP MAPK6 PGS1 PITX2 RLIM RPS6KA5 STK35 SUPT4H1 VIM
Entrez ID		5308	9124
HPRD ID		03328	09326
Ensembl ID		ENSG00000164093	ENSG00000107438
Uniprot IDs		Q99697	O00151 V9HW92
PDB IDs		2L7F 2L7M 2LKX	1X62 2PKT
Enriched GO Terms of Interacting Partners?
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