TRIM25 and MAP3K13

Number of citations of the paper that reports this interaction (PubMedID 31186535)
1

Data Source:
BioGRID (enzymatic study)

		TRIM25	MAP3K13
Description		tripartite motif containing 25	mitogen-activated protein kinase kinase kinase 13
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Cytoplasmic Stress Granule Nuclear Body	Cytoplasm Membrane
	Molecular Function	RNA Binding Protein Binding Ligase Activity RIG-I Binding Cadherin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Enzyme Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding IkappaB Kinase Complex Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Viral Process Translesion Synthesis Ubiquitin-dependent ERAD Pathway Negative Regulation Of Type I Interferon Production Response To Vitamin D RIG-I Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Estrogen Innate Immune Response Regulation Of Viral Entry Into Host Cell Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Interferon-gamma-mediated Signaling Pathway Regulation Of Viral Release From Host Cell Negative Regulation Of Viral Release From Host Cell Cellular Response To Leukemia Inhibitory Factor	Activation Of MAPKK Activity Protein Phosphorylation JNK Cascade Activation Of JNKK Activity Activation Of JUN Kinase Activity Positive Regulation Of Neuron Maturation Peptidyl-serine Phosphorylation Positive Regulation Of Axon Extension Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Neuron Projection Arborization Positive Regulation Of Branching Morphogenesis Of A Nerve
Pathways		ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Termination of translesion DNA synthesis Ovarian tumor domain proteases Interferon gamma signaling TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS		Height ( 18391951) Lean body mass ( 28552196)	Airflow obstruction ( 22837378) Arterial stiffness index ( 31235810) Major depressive disorder ( 27519822)
Interacting Genes		36 interacting genes: AMFR APC ERCC2 ERG ESR1 GATA1 GRIK2 MAP3K13 MEIS2 MTA1 OTUB2 PAX2 PITX2 PLAAT4 RBCK1 RNF31 SFN STK11 STK38 TFG TRAF6 TRIM8 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2J2 UBE2L3 UBE2L6 UBE2N UBE2V1 USP15 USP39 ZC3HAV1 ZNF24	8 interacting genes: GLO1 HLA-DRB3 IKBKB MAP2K7 MAPK8IP1 PRDX3 STAT3 TRIM25
Entrez ID		7706	9175
HPRD ID		02711	05372
Ensembl ID		ENSG00000121060	ENSG00000073803
Uniprot IDs		Q14258	O43283
PDB IDs		4CFG 4LTB 5EYA 5FER 5NT1 5NT2 6FLM 6FLN
Enriched GO Terms of Interacting Partners?
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