U2AF2 and DACH1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		U2AF2	DACH1
Description		U2 small nuclear RNA auxiliary factor 2	dachshund family transcription factor 1
Image
GO Annotations	Cellular Component	Commitment Complex Prp19 Complex Nucleus Nucleoplasm Spliceosomal Complex Nuclear Speck U2-type Prespliceosome U2AF	Nucleus Transcription Factor Complex Cytoplasm
	Molecular Function	RNA Binding Protein Binding Poly-pyrimidine Tract Binding Enzyme Binding Pre-mRNA 3'-splice Site Binding C2H2 Zinc Finger Domain Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Export From Nucleus MRNA Export From Nucleus MRNA 3'-end Processing Negative Regulation Of Protein Ubiquitination Positive Regulation Of RNA Splicing Negative Regulation Of MRNA Splicing, Via Spliceosome	Negative Regulation Of Transcription By RNA Polymerase II Suckling Behavior Regulation Of Transcription, DNA-templated Respiratory Gaseous Exchange Cell Proliferation Negative Regulation Of Transcription By Competitive Promoter Binding Negative Regulation Of Cell Migration Regulation Of Nuclear Cell Cycle DNA Replication Negative Regulation Of Transcription, DNA-templated Development Of Primary Female Sexual Characteristics Negative Regulation Of Fibroblast Proliferation Negative Regulation Of Cell Proliferation Involved In Contact Inhibition Negative Regulation Of DNA Biosynthetic Process
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS		Menopause (age at onset) ( 26414677)	Adverse response to lamotrigine and phenytoin ( 22379998) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Blood urea nitrogen levels ( 31152163 29403010) Chronic kidney disease ( 20383146) Chronotype ( 30696823) Cleft palate ( 30452639) Creatinine levels ( 29403010) Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate ( 29403010) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Longevity ( 20834067) Medication use (diuretics) ( 31015401) Metabolite levels ( 23823483) Obsessive-compulsive disorder ( 22889921) Plateletcrit ( 27863252) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Restless legs syndrome ( 29029846) Serum uric acid levels ( 30993211) Stroke ( 29531354) Total cholesterol levels ( 30498476) Ulna and radius bone mineral density ( 30172743) Urate levels ( 31578528 23263486) Verbal declarative memory ( 25648963) White blood cell count ( 31217584)
Interacting Genes		47 interacting genes: APBB1 ATXN1 BEND7 CCAR1 CHERP CHIC2 CPSF7 DACH1 DDX6 DPPA2 DVL2 EPB41 GEMIN2 GLIS2 HLA-DMA IL7R KHDC4 KHDRBS3 LURAP1 MAP1B OTUB2 PIN1 POLR2A PRPF3 PRPF40A PUF60 QKI RBFOX2 RBM39 RBM4 SAP30BP SCAF11 SF1 SMAD5 SNRPA SRPK1 SRPK2 SRSF1 SRSF11 SUGP1 TCERG1 THAP1 TLE5 TOP1 U2AF1 WT1 ZRSR2	31 interacting genes: AHCYL1 AURKA C1orf35 CREBBP EYA1 EYA3 FGF12 FOXO1 JUN MYC MYCBP2 NAGK NCOR1 NF2 NFIC PPIG RNF14 SIN3A SIX1 SMAD1 SMAD3 SMAD4 SOX3 SOX4 STK11 TCF3 TEAD2 TERT U2AF2 UBE2I ZCCHC10
Entrez ID		11338	1602
HPRD ID		01872	16031
Ensembl ID		ENSG00000063244	ENSG00000276644
Uniprot IDs		P26368	Q9UI36
PDB IDs		1JMT 1O0P 1OPI 1U2F 2G4B 2HZC 2M0G 2U2F 2YH0 2YH1 3VAF 3VAG 3VAH 3VAI 3VAJ 3VAK 3VAL 3VAM 4FXW 4TU7 4TU8 4TU9 5EV1 5EV2 5EV3 5EV4 5W0G 5W0H	1L8R
Enriched GO Terms of Interacting Partners?
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