ZAP70 and CBLB

Number of citations of the paper that reports this interaction (PubMedID 21453975)
14

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		ZAP70	CBLB
Description		zeta chain of T cell receptor associated protein kinase 70	Cbl proto-oncogene B
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GO Annotations	Cellular Component	Immunological Synapse Cytoplasm Cytosol Plasma Membrane Cell-cell Junction T Cell Receptor Complex Membrane Raft	Nucleoplasm Cytosol Plasma Membrane Membrane Raft
	Molecular Function	Phosphotyrosine Residue Binding Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding	Phosphotyrosine Residue Binding Calcium Ion Binding Protein Binding Zinc Ion Binding SH3 Domain Binding Receptor Tyrosine Kinase Binding Ubiquitin Protein Ligase Activity
	Biological Process	Adaptive Immune Response Protein Phosphorylation Immune Response Peptidyl-tyrosine Phosphorylation T Cell Differentiation Intracellular Signal Transduction T Cell Activation B Cell Activation Beta Selection Positive Thymic T Cell Selection Negative Thymic T Cell Selection Positive Regulation Of T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Protein Autophosphorylation Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway T Cell Aggregation T Cell Migration	NLS-bearing Protein Import Into Nucleus Signal Transduction Cell Surface Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Ubiquitination Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway
Pathways		Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Staurosporine
Diseases		Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS		Bipolar disorder ( 31043756) Cardiac Troponin-T levels ( 31014085) Diastolic blood pressure ( 30224653)	Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Antipsychotic drug-induced weight gain in schizophrenia or autism ( 31447353) Estimated glomerular filtration rate ( 31152163) Itch intensity from mosquito bite ( 28199695) Mosquito bite size ( 28199695) Multiple sclerosis ( 31604244 20453840 28445677) Waist circumference ( 31647587) Zinc levels ( 26025379)
Interacting Genes		62 interacting genes: ABL1 ACP1 ANAPC11 APP ASB3 CARD11 CBL CBLB CBLC CD247 CD3E CD5 CD79B CRK CSK DAPK1 DBNL DEF6 DUSP3 EGFR ERBB3 FCGR3A FCRL3 FYN GAB2 GRB2 IFNAR1 LAT LAX1 LCK LCP2 LRRK2 MUC1 NDUFB8 NFAM1 NR0B2 PAG1 PLCG1 PRLR PTK2B PTPN22 PTPN3 PTPN6 PTPRC RASA1 RNF41 SH2B3 SH3BP2 SHB SHC1 SIT1 SLA SLA2 SLAMF6 SOS1 TUBA1A TUBA4A TUBB TYROBP USP2 VAV1 WIPF1	46 interacting genes: APPL1 ARHGEF7 BLNK CD2AP CRK CRKL CRY1 DAPK1 DUXAP9 EGFR FLT3 FYB1 FYN GLRX3 GORASP2 GRAP2 GRB2 HNRNPK KIT LRRK1 LRRK2 MFHAS1 NCK1 NCK2 NEDD4 NEDD8 PIK3R1 PLCG2 PRMT2 RET RNF11 SH3KBP1 SHC1 SORBS3 SP7 SPRY2 SYK TGFB1I1 TNFRSF11A UBASH3B UBC UBE2D2 UBE2L3 VAV1 VAV2 ZAP70
Entrez ID		7535	868
HPRD ID		01495	05136
Ensembl ID		ENSG00000115085	ENSG00000114423
Uniprot IDs		P43403	B3KSS7 B4DYP3 B7ZAG1 H0Y3L9 Q13191
PDB IDs		1FBV 1M61 1U59 2CBL 2OQ1 2OZO 2Y1N 3ZNI 4A4B 4A4C 4K2R 4XZ0 4XZ1 5O76	2AK5 2BZ8 2DO6 2J6F 2JNH 2LDR 2OOA 2OOB 3PFV 3VGO 3ZNI
Enriched GO Terms of Interacting Partners?
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