ZAP70 and NR0B2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		ZAP70	NR0B2
Description		zeta chain of T cell receptor associated protein kinase 70	nuclear receptor subfamily 0 group B member 2
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GO Annotations	Cellular Component	Immunological Synapse Cytoplasm Cytosol Plasma Membrane Cell-cell Junction T Cell Receptor Complex Membrane Raft	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Protein-containing Complex
	Molecular Function	Phosphotyrosine Residue Binding Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Steroid Hormone Receptor Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Protein Domain Specific Binding Protein Homodimerization Activity Peroxisome Proliferator Activated Receptor Binding Protein-containing Complex Binding Retinoid X Receptor Binding Thyroid Hormone Receptor Binding
	Biological Process	Adaptive Immune Response Protein Phosphorylation Immune Response Peptidyl-tyrosine Phosphorylation T Cell Differentiation Intracellular Signal Transduction T Cell Activation B Cell Activation Beta Selection Positive Thymic T Cell Selection Negative Thymic T Cell Selection Positive Regulation Of T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Protein Autophosphorylation Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway T Cell Aggregation T Cell Migration	Negative Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Notch Signaling Pathway Circadian Rhythm Cholesterol Metabolic Process Response To Glucose Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Animal Organ Regeneration Positive Regulation Of Insulin Secretion Circadian Regulation Of Gene Expression Steroid Hormone Mediated Signaling Pathway Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated
Pathways		Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules	Nuclear Receptor transcription pathway
Drugs		Staurosporine
Diseases		Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS		Bipolar disorder ( 31043756) Cardiac Troponin-T levels ( 31014085) Diastolic blood pressure ( 30224653)	Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) HDL cholesterol ( 24097068) LDL cholesterol ( 24097068) Triglycerides ( 24097068)
Interacting Genes		62 interacting genes: ABL1 ACP1 ANAPC11 APP ASB3 CARD11 CBL CBLB CBLC CD247 CD3E CD5 CD79B CRK CSK DAPK1 DBNL DEF6 DUSP3 EGFR ERBB3 FCGR3A FCRL3 FYN GAB2 GRB2 IFNAR1 LAT LAX1 LCK LCP2 LRRK2 MUC1 NDUFB8 NFAM1 NR0B2 PAG1 PLCG1 PRLR PTK2B PTPN22 PTPN3 PTPN6 PTPRC RASA1 RNF41 SH2B3 SH3BP2 SHB SHC1 SIT1 SLA SLA2 SLAMF6 SOS1 TUBA1A TUBA4A TUBB TYROBP USP2 VAV1 WIPF1	49 interacting genes: AR CHRD DDX20 EID1 ESR1 ESR2 ESRRA ESRRG FN1 GPS2 HDAC3 HDAC6 HNF4A HNF4G HNRNPA1 ID2 IL3RA NCOA3 NEUROD1 NR1H2 NR1H3 NR1I2 NR1I3 NR3C1 NR5A2 PAX9 PEF1 PLSCR1 POLR2A PPARD PPARG RARA RARG RBP5 RNF31 RXRA RXRB RXRG SMAD4 SMARCA2 SMARCB1 SMARCE1 SNW1 THRA TP53 VDR XBP1 ZAP70 ZMYND10
Entrez ID		7535	8431
HPRD ID		01495	05219
Ensembl ID		ENSG00000115085	ENSG00000131910
Uniprot IDs		P43403	Q15466
PDB IDs		1FBV 1M61 1U59 2CBL 2OQ1 2OZO 2Y1N 3ZNI 4A4B 4A4C 4K2R 4XZ0 4XZ1 5O76	1YUC 2Q3Y 2Z4J 4DOR 4ONI 5UFS
Enriched GO Terms of Interacting Partners?
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