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XPC and GTF2H1
Number of citations of the paper that reports this interaction (PubMedID
11259578
)
62
Data Source:
HPRD
(in vivo)
XPC
GTF2H1
Description
XPC complex subunit, DNA damage recognition and repair factor
general transcription factor IIH subunit 1
Image
GO Annotations
Cellular Component
Nucleotide-excision Repair Complex
Nucleotide-excision Repair Factor 2 Complex
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Mitochondrion
Cytosol
Plasma Membrane
Intracellular Membrane-bounded Organelle
XPC Complex
Site Of DNA Damage
Transcription Factor TFIIH Core Complex
Nucleoplasm
Transcription Factor TFIIH Holo Complex
Molecular Function
Heteroduplex DNA Loop Binding
Bubble DNA Binding
Damaged DNA Binding
Single-stranded DNA Binding
Transcription Coactivator Activity
Protein Binding
Protein-containing Complex Binding
Chromatin Binding
Protein Kinase Activity
Protein Binding
DNA-dependent ATPase Activity
RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity
Biological Process
Nucleotide-excision Repair, DNA Damage Recognition
Nucleotide-excision Repair, DNA Duplex Unwinding
Pyrimidine Dimer Repair By Nucleotide-excision Repair
DNA Repair
Nucleotide-excision Repair
Nucleotide-excision Repair, Preincision Complex Assembly
Mismatch Repair
Response To UV-B
Response To Auditory Stimulus
Intra-S DNA Damage Checkpoint
Response To Drug
Positive Regulation Of Transcription, DNA-templated
Global Genome Nucleotide-excision Repair
UV-damage Excision Repair
Regulation Of Mitotic Cell Cycle Phase Transition
UV-damage Excision Repair, DNA Incision
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Nucleotide-excision Repair, DNA Duplex Unwinding
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Nucleotide-excision Repair, Preincision Complex Stabilization
Nucleotide-excision Repair, Preincision Complex Assembly
Nucleotide-excision Repair, DNA Incision, 3'-to Lesion
Nucleotide-excision Repair, DNA Incision, 5'-to Lesion
Transcription By RNA Polymerase I
Transcription Initiation From RNA Polymerase I Promoter
Transcription Elongation From RNA Polymerase I Promoter
Termination Of RNA Polymerase I Transcription
Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Transcription Elongation From RNA Polymerase II Promoter
7-methylguanosine MRNA Capping
Nucleotide-excision Repair, DNA Incision
Positive Regulation Of Transcription By RNA Polymerase II
Phosphorylation Of RNA Polymerase II C-terminal Domain
Global Genome Nucleotide-excision Repair
Pathways
SUMOylation of DNA damage response and repair proteins
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Tat-mediated elongation of the HIV-1 transcript
NoRC negatively regulates rRNA expression
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
mRNA Capping
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase I Transcription Termination
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Pol II CTD phosphorylation and interaction with CE
Drugs
Diseases
Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS
Amyloid A serum levels (
21124955
)
Blood protein levels (
28240269
)
Pancreatic cancer (
23180869
)
Serum metabolite levels (
23093944
)
Survival in pancreatic cancer (
28470677
)
Interacting Genes
16 interacting genes:
CETN2
DDB2
ERCC3
GTF2H1
LSM3
MDM2
MRPS25
PSMD4
RAD23A
RAD23B
RPA1
SMAD1
TDG
USP7
XPA
ZNF512B
44 interacting genes:
ACTN1
AR
ATF7IP
BRPF1
CCNH
CCSER2
CDK7
E2F1
ERCC2
ERCC3
ERCC4
ERCC5
ESR1
FUBP1
GTF2E1
GTF2E2
GTF2H2
GTF2H3
HNF4A
HNRNPU
HOXC11
JDP2
KIF13A
KPNA3
MCM2
MMS19
MNAT1
PIK3R1
PLCG1
POLR2A
POU2AF1
PSMC2
RAD23A
REEP5
RXRB
TNIP1
TP53
TRIOBP
TXNRD2
UBC
USHBP1
XPA
XPC
ZSCAN1
Entrez ID
7508
2965
HPRD ID
02046
01807
Ensembl ID
ENSG00000154767
ENSG00000110768
Uniprot IDs
Q01831
X5DRB1
A0A384MTQ8
P32780
PDB IDs
2A4J
2GGM
2OBH
2RVB
1PFJ
2DII
2RNR
2RUK
2RVB
5GOW
5XV8
6NMI
6O9L
6O9M
Enriched GO Terms of Interacting Partners
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