SUMO1 and MYB

Number of citations of the paper that reports this interaction (PubMedID 20802522)
9

Data Source:
BioGRID (pull down)

		SUMO1	MYB
Description		small ubiquitin like modifier 1	MYB proto-oncogene, transcription factor
Image			No pdb structure
GO Annotations	Cellular Component	Heterochromatin Fibrillar Center XY Body Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Nucleolus Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex Nuclear Body PML Body Nuclear Speck Dendrite SUMO Activating Enzyme Complex Nuclear Membrane Synapse Nuclear Stress Granule	Nucleus Nucleoplasm Cytosol Nuclear Matrix
	Molecular Function	Transcription Corepressor Binding RNA Binding Protein Binding Protein C-terminus Binding Transcription Factor Binding Potassium Channel Regulator Activity Enzyme Binding Protein Binding, Bridging Protein Tag Ubiquitin Protein Ligase Binding Glucocorticoid Receptor Binding Small Protein Activating Enzyme Binding Ubiquitin-like Protein Ligase Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Double-strand Break Repair Via Nonhomologous End Joining Viral Process Protein Sumoylation PML Body Organization Positive Regulation Of Protein Complex Assembly Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Cellular Response To Heat Negative Regulation Of DNA Binding Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Action Potential Negative Regulation Of Transcription, DNA-templated Protein Stabilization Roof Of Mouth Development Regulation Of Interferon-gamma-mediated Signaling Pathway Cellular Response To Cadmium Ion Regulation Of Cardiac Muscle Cell Contraction Protein Localization To Nuclear Pore Positive Regulation Of Calcium-transporting ATPase Activity Negative Regulation Of Delayed Rectifier Potassium Channel Activity	Negative Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle Response To Hypoxia Chromatin Remodeling Regulation Of Transcription, DNA-templated Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of T-helper Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of Histone H3-K9 Methylation Positive Regulation Of Glial Cell Proliferation Cellular Response To Hydrogen Peroxide Cellular Response To Retinoic Acid Positive Regulation Of Transforming Growth Factor Beta Production Regulation Of Hematopoietic Stem Cell Differentiation Positive Regulation Of Hepatic Stellate Cell Proliferation Positive Regulation Of Hepatic Stellate Cell Activation Positive Regulation Of Testosterone Secretion
Pathways		SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is proteolytically processed SUMOylation of DNA damage response and repair proteins SUMO E3 ligases SUMOylate target proteins SUMOylation of transcription factors SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins SUMOylation of transcription cofactors SUMOylation of transcription cofactors SUMOylation of SUMOylation proteins SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins SUMOylation of DNA methylation proteins SUMOylation of DNA methylation proteins SUMOylation of immune response proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Formation of Incision Complex in GG-NER G2/M DNA damage checkpoint Regulation of IFNG signaling Negative regulation of activity of TFAP2 (AP-2) family transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Postmitotic nuclear pore complex (NPC) reformation	RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Transcriptional regulation of granulopoiesis Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS			Aspartate aminotransferase levels ( 29403010) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Beta thalassemia/hemoglobin E disease ( 20183929) Eosinophil counts ( 29403010) Fetal hemoglobin levels in sickle cell anemia ( 25372704) Glycated hemoglobin levels ( 24647736 28898252) HbA2 levels ( 23043469) Hematocrit ( 29403010 19862010) Hematological and biochemical traits ( 20139978) Hematological parameters ( 19820697) Hematology traits ( 23263863) Hemoglobin ( 29403010) Hemoglobin A1c levels ( 29403010) Hemoglobin levels ( 26366553) Hodgkin's lymphoma ( 24149102) Mean corpuscular hemoglobin ( 23263863 29403010 19853236 28453575 20139978 28548082 19862010) Mean corpuscular hemoglobin concentration ( 23263863 29403010 20139978) Mean corpuscular volume ( 23263863 29403010 19853236 28453575 20139978 19862010) Multiple sclerosis ( 21833088) Myeloproliferative neoplasms ( 25849990) Obesity-related traits ( 23251661) Other erythrocyte phenotypes ( 19862010) Platelet count ( 26805783 22139419 24026423 29066854 29403010 19853236 22423221 20139978) Red blood cell count ( 29403010 28453575 20139978) Red blood cell traits ( 20927387 23935956) White blood cell count ( 29403010 20139978) White blood cell count (basophil) ( 27863252) White blood cell types ( 21738478)
Interacting Genes		139 interacting genes: AR ATF2 ATXN1 ATXN3 ATXN7 AXIN1 BIRC3 BLM BRCA1 C11orf65 C18orf25 CANX CARD9 CASP2 CASP8 CDK6 CHAF1A CHD3 CREBBP DAXX DEUP1 DNM1 DNMT3B DTX2 EDARADD EGLN3 ETV6 FAF1 FAM118B FAS FASLG FBF1 FOS FOXM1 GMCL1 HDAC4 HDAC9 HGS HIF1A HIPK2 HIPK3 HNRNPC HNRNPK HSF1 HTT IKZF3 IRAK1 JUN MAPK1IP1L MDM2 MEF2A MITF MRTFA MSX1 MTOR MUL1 MYB NCOA1 NCOA2 NCOA3 NCOR2 NFE2L2 NFKBIA NIN NR3C1 NR3C2 PARK7 PAX6 PCNA PDGFC PHC1 PIAS1 PIAS2 PIAS3 PIAS4 PKM PLAGL1 PML PPM1J PRKN PSIP1 RAD51 RAD52 RAD54B RAD54L2 RANBP2 RANGAP1 RHOXF2 RNF111 RNF4 RPS3 SAE1 SALL1 SATB1 SENP1 SENP2 SENP6 SETX SLC2A1 SOX10 SOX2 SOX6 SP100 SP3 SPOP SREBF1 SREBF2 SUMO1P1 TDG TDP2 TFCP2 TNFRSF1A TOE1 TOP1 TOP2A TOP2B TOPORS TP53 TP73 TRAF4 TRIM24 TRPS1 TSC22D3 UBA2 UBE2I USP25 USPL1 WRN XPO1 ZBTB16 ZBTB26 ZBTB6 ZCCHC12 ZCCHC7 ZHX1 ZMYM2 ZMYM3 ZMYM5 ZNF451	48 interacting genes: BTRC CCND3 CEBPB CEBPE CHD3 CNOT9 CREBBP CSNK2A1 EP300 ERC2 FBXW2 FBXW5 FBXW7 H2AC4 H2BC3 H3-4 H3C1 H4C1 HIPK2 HLF KAT2A MAF MAPK1 MYBBP1A MYOZ2 NCL NCOR1 NLK PAX5 PIAS1 PML PPM1K RBX1 RPL4 SIN3A SKI SKP2 SMARCA2 SND1 SP100 SUMO1 SUMO2 TRIM28 TTF2 UBE2I UPF2 ZFHX3 ZMYND11
Entrez ID		7341	4602
HPRD ID		03554	01810
Ensembl ID		ENSG00000116030	ENSG00000118513
Uniprot IDs		A0A024R3Z2 P63165	P10242 Q708E9
PDB IDs		1A5R 1TGZ 1WYW 1Y8R 1Z5S 2ASQ 2BF8 2G4D 2IO2 2IY0 2IY1 2KQS 2LAS 2MW5 2N1A 2N1V 2PE6 2UYZ 2VRR 3KYC 3KYD 3RZW 3UIP 4WJN 4WJO 4WJP 4WJQ 5AEK 5B7A 5ELJ 5GHD 6EOP 6EOT 6J4I 6K5T 6UYO 6UYP 6UYQ 6UYR 6UYS 6UYT 6UYU 6UYV 6UYX 6UYY 6UYZ
Enriched GO Terms of Interacting Partners?
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