MYB and HLF

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		MYB	HLF
Description		MYB proto-oncogene, transcription factor	HLF transcription factor, PAR bZIP family member
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Nuclear Matrix	Nuclear Chromatin Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle Response To Hypoxia Chromatin Remodeling Regulation Of Transcription, DNA-templated Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of T-helper Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of Histone H3-K9 Methylation Positive Regulation Of Glial Cell Proliferation Cellular Response To Hydrogen Peroxide Cellular Response To Retinoic Acid Positive Regulation Of Transforming Growth Factor Beta Production Regulation Of Hematopoietic Stem Cell Differentiation Positive Regulation Of Hepatic Stellate Cell Proliferation Positive Regulation Of Hepatic Stellate Cell Activation Positive Regulation Of Testosterone Secretion	Transcription By RNA Polymerase II Multicellular Organism Development Skeletal Muscle Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process
Pathways		RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Transcriptional regulation of granulopoiesis Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 29403010) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Beta thalassemia/hemoglobin E disease ( 20183929) Eosinophil counts ( 29403010) Fetal hemoglobin levels in sickle cell anemia ( 25372704) Glycated hemoglobin levels ( 24647736 28898252) HbA2 levels ( 23043469) Hematocrit ( 29403010 19862010) Hematological and biochemical traits ( 20139978) Hematological parameters ( 19820697) Hematology traits ( 23263863) Hemoglobin ( 29403010) Hemoglobin A1c levels ( 29403010) Hemoglobin levels ( 26366553) Hodgkin's lymphoma ( 24149102) Mean corpuscular hemoglobin ( 23263863 29403010 19853236 28453575 20139978 28548082 19862010) Mean corpuscular hemoglobin concentration ( 23263863 29403010 20139978) Mean corpuscular volume ( 23263863 29403010 19853236 28453575 20139978 19862010) Multiple sclerosis ( 21833088) Myeloproliferative neoplasms ( 25849990) Obesity-related traits ( 23251661) Other erythrocyte phenotypes ( 19862010) Platelet count ( 26805783 22139419 24026423 29066854 29403010 19853236 22423221 20139978) Red blood cell count ( 29403010 28453575 20139978) Red blood cell traits ( 20927387 23935956) White blood cell count ( 29403010 20139978) White blood cell count (basophil) ( 27863252) White blood cell types ( 21738478)	Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced) ( 24236485) Bipolar disorder ( 31043756) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Serum uric acid levels ( 30993211) Urate levels ( 31578528 23263486) Urate levels in obese individuals ( 25811787) Waist circumference ( 28552196) Weight ( 28552196) Zinc levels ( 26025379)
Interacting Genes		48 interacting genes: BTRC CCND3 CEBPB CEBPE CHD3 CNOT9 CREBBP CSNK2A1 EP300 ERC2 FBXW2 FBXW5 FBXW7 H2AC4 H2BC3 H3-4 H3C1 H4C1 HIPK2 HLF KAT2A MAF MAPK1 MYBBP1A MYOZ2 NCL NCOR1 NLK PAX5 PIAS1 PML PPM1K RBX1 RPL4 SIN3A SKI SKP2 SMARCA2 SND1 SP100 SUMO1 SUMO2 TRIM28 TTF2 UBE2I UPF2 ZFHX3 ZMYND11	5 interacting genes: ARNTL CREBBP DBP HNF4G MYB
Entrez ID		4602	3131
HPRD ID		01810	00797
Ensembl ID		ENSG00000118513	ENSG00000108924
Uniprot IDs		P10242 Q708E9	Q16534
PDB IDs
Enriched GO Terms of Interacting Partners?
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