SUMO1 and AXIN1

Number of citations of the paper that reports this interaction (PubMedID 26871637)
108

Data Source:
BioGRID (two hybrid)

		SUMO1	AXIN1
Description		small ubiquitin like modifier 1	axin 1
Image
GO Annotations	Cellular Component	Heterochromatin Fibrillar Center XY Body Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Nucleolus Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex Nuclear Body PML Body Nuclear Speck Dendrite SUMO Activating Enzyme Complex Nuclear Membrane Synapse Nuclear Stress Granule	Nucleus Cytoplasm Cytosol Lateral Plasma Membrane Beta-catenin Destruction Complex Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Cell Periphery
	Molecular Function	Transcription Corepressor Binding RNA Binding Protein Binding Protein C-terminus Binding Transcription Factor Binding Potassium Channel Regulator Activity Enzyme Binding Protein Binding, Bridging Protein Tag Ubiquitin Protein Ligase Binding Glucocorticoid Receptor Binding Small Protein Activating Enzyme Binding Ubiquitin-like Protein Ligase Binding	Protein Binding Beta-catenin Binding Enzyme Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Signaling Adaptor Activity Identical Protein Binding Protein Homodimerization Activity SMAD Binding Molecular Adaptor Activity Armadillo Repeat Domain Binding I-SMAD Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Double-strand Break Repair Via Nonhomologous End Joining Viral Process Protein Sumoylation PML Body Organization Positive Regulation Of Protein Complex Assembly Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Cellular Response To Heat Negative Regulation Of DNA Binding Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Action Potential Negative Regulation Of Transcription, DNA-templated Protein Stabilization Roof Of Mouth Development Regulation Of Interferon-gamma-mediated Signaling Pathway Cellular Response To Cadmium Ion Regulation Of Cardiac Muscle Cell Contraction Protein Localization To Nuclear Pore Positive Regulation Of Calcium-transporting ATPase Activity Negative Regulation Of Delayed Rectifier Potassium Channel Activity	Positive Regulation Of Protein Phosphorylation Apoptotic Process Multicellular Organism Development Positive Regulation Of Peptidyl-threonine Phosphorylation Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Positive Regulation Of Protein Ubiquitination Activation Of Protein Kinase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Intracellular Estrogen Receptor Signaling Pathway Cellular Protein-containing Complex Assembly Positive Regulation Of Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of JNK Cascade Positive Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Beta-catenin Destruction Complex Assembly Beta-catenin Destruction Complex Disassembly Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is proteolytically processed SUMOylation of DNA damage response and repair proteins SUMO E3 ligases SUMOylate target proteins SUMOylation of transcription factors SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins SUMOylation of transcription cofactors SUMOylation of transcription cofactors SUMOylation of SUMOylation proteins SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins SUMOylation of DNA methylation proteins SUMOylation of DNA methylation proteins SUMOylation of immune response proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Formation of Incision Complex in GG-NER G2/M DNA damage checkpoint Regulation of IFNG signaling Negative regulation of activity of TFAP2 (AP-2) family transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Postmitotic nuclear pore complex (NPC) reformation	Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade TCF dependent signaling in response to WNT Degradation of AXIN Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Misspliced GSK3beta mutants stabilize beta-catenin S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Ub-specific processing proteases RUNX1 regulates estrogen receptor mediated transcription RUNX1 regulates transcription of genes involved in WNT signaling Estrogen-dependent gene expression
Drugs			1,4-Dithiothreitol
Diseases			Hepatocellular carcinoma Caudal duplication anomaly
GWAS			Body mass index ( 25673413) Bone mineral density (spine) ( 26733130) Femoral neck bone mineral density ( 29499414) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Lumbar spine bone mineral density ( 29499414 22504420) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular hemoglobin concentration ( 27863252) Mean corpuscular volume ( 27863252) Red blood cell count ( 27863252) Red cell distribution width ( 27863252)
Interacting Genes		139 interacting genes: AR ATF2 ATXN1 ATXN3 ATXN7 AXIN1 BIRC3 BLM BRCA1 C11orf65 C18orf25 CANX CARD9 CASP2 CASP8 CDK6 CHAF1A CHD3 CREBBP DAXX DEUP1 DNM1 DNMT3B DTX2 EDARADD EGLN3 ETV6 FAF1 FAM118B FAS FASLG FBF1 FOS FOXM1 GMCL1 HDAC4 HDAC9 HGS HIF1A HIPK2 HIPK3 HNRNPC HNRNPK HSF1 HTT IKZF3 IRAK1 JUN MAPK1IP1L MDM2 MEF2A MITF MRTFA MSX1 MTOR MUL1 MYB NCOA1 NCOA2 NCOA3 NCOR2 NFE2L2 NFKBIA NIN NR3C1 NR3C2 PARK7 PAX6 PCNA PDGFC PHC1 PIAS1 PIAS2 PIAS3 PIAS4 PKM PLAGL1 PML PPM1J PRKN PSIP1 RAD51 RAD52 RAD54B RAD54L2 RANBP2 RANGAP1 RHOXF2 RNF111 RNF4 RPS3 SAE1 SALL1 SATB1 SENP1 SENP2 SENP6 SETX SLC2A1 SOX10 SOX2 SOX6 SP100 SP3 SPOP SREBF1 SREBF2 SUMO1P1 TDG TDP2 TFCP2 TNFRSF1A TOE1 TOP1 TOP2A TOP2B TOPORS TP53 TP73 TRAF4 TRIM24 TRPS1 TSC22D3 UBA2 UBE2I USP25 USPL1 WRN XPO1 ZBTB16 ZBTB26 ZBTB6 ZCCHC12 ZCCHC7 ZHX1 ZMYM2 ZMYM3 ZMYM5 ZNF451	83 interacting genes: AMER1 ANP32A APC BTRC CALCOCO2 CARD9 CARM1 CCDC57 CDCA7L CRMP1 CSNK1A1 CSNK1E CTNNB1 DAB2 DIXDC1 DVL1 DVL2 DVL3 EEF1A1 ENTR1 ETV6 GAK GMCL1 GNAS GOLGA2 GSK3B HOMEZ JUP KRT40 KRTAP10-3 KRTAP4-12 KRTAP4-2 LHX4 LHX8 LMO2 LRP5 LRP6 MAP3K4 MDFI MEOX2 MID2 MTUS2 MYC MYOT NBR1 NCK2 NUTM1 PIAS1 PML PPP2CA PPP2CB PPP2R5B PPP2R5C PRMT1 PSTPIP1 RNF111 RUNX2 SCYL1 SENP2 SH3GL1 SIAH1 SMAD2 SMAD3 SMAD7 SMURF1 SMURF2 STX11 SUMO1 SUMO1P1 TFIP11 TNKS TP53 TP53BP2 TRAF2 TRIM15 TRIM27 TRIM37 TRIM42 TRIP6 TSGA10 UTP14A ZBTB26 ZFYVE19
Entrez ID		7341	8312
HPRD ID		03554	04819
Ensembl ID		ENSG00000116030	ENSG00000103126
Uniprot IDs		A0A024R3Z2 P63165	A0A0S2Z4R0 A0A0S2Z4S3 O15169
PDB IDs		1A5R 1TGZ 1WYW 1Y8R 1Z5S 2ASQ 2BF8 2G4D 2IO2 2IY0 2IY1 2KQS 2LAS 2MW5 2N1A 2N1V 2PE6 2UYZ 2VRR 3KYC 3KYD 3RZW 3UIP 4WJN 4WJO 4WJP 4WJQ 5AEK 5B7A 5ELJ 5GHD 6EOP 6EOT 6J4I 6K5T 6UYO 6UYP 6UYQ 6UYR 6UYS 6UYT 6UYU 6UYV 6UYX 6UYY 6UYZ	1DK8 1EMU 1O9U 3ZDI 4B7T 4NM0 4NM3 4NM5 4NM7 4NU1 5WZZ
Enriched GO Terms of Interacting Partners?
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